PPT-Gluconeogenesis

Introduction Glucose remains the nearly universal and building block in modern organisms from microbes to humans In mammals some tissues depend almost completely on glucose for their metabolic energy . C483 Spring 2013. 1. An . intermediate found in gluconeogenesis and not glycolysis is. A) 2-phosphoglycerate.. B) oxaloacetate.. C) . phosphoenolpyruvate. .. D) fructose 1,6-bisphosphate.. 2. In the Cori Cycle, _____ is transported through blood to the liver, where it is made into ________ and then ___________ for transport out of the liver.. In glycolysis, these enzymes are . Hexokinase. Phosphofructokinase. P. yruvate kinase. Phosphofructokinase is the key regulator of glycolysis in mammals. The enzyme is allosterically inhibited by ATP and allosterically stimulated by AMP.. Metabolism. (Gluconeogenesis). Objectives. The . importance of . gluconeogenesis. as an important pathway for glucose production. The . main reactions of . gluconeogenesis. The . rate-limiting enzymes of . Chapter 17 . Stryer. Short Course. Glucose Metabolism Overview. Gluconeogenesis. Glycogen . metabolism. Pentose Phosphate Pathway. Precursors for Gluconeogenesis. Names of compounds?. Type of reaction?. C483 Spring 2013. 1. An . intermediate found in gluconeogenesis and not glycolysis is. A) 2-phosphoglycerate.. B) oxaloacetate.. C) . phosphoenolpyruvate. .. D) fructose 1,6-bisphosphate.. 2. In the Cori Cycle, _____ is transported through blood to the liver, where it is made into ________ and then ___________ for transport out of the liver.. Metabolism. Chapter 10: Gluconeogenesis. I. . OVERVIEW. Some tissues, such as the brain, red blood cells (RBCs), kidney medulla. , lens . and cornea of the eye, testes, and exercising muscle, require a . Part II. Dr. Kevin Ahern. Glycolysis. Summary. Glucose 2 ADP 2P. i. 2 NAD. . Yields. 2 Pyruvate 2 ATP 2 NADH 2 H. . 2 H. 2. O . Glycolysis. Fermentation in Yeast/Bacteria. Glucose. GA3P. 2. Glucose used g/h. Time. Sources of Glucose & its Consumption. Exogenous (diet). Body glycogen. Gluconeogenesis. Gluco. = Glucose, neo= new, genesis= creation. http://www.medgadget.com/archives/img/Kidney05-full.jpg. Department . of Pediatrics, Pediatric Endocrinology, . Diabetology. and Neurology. . Provincial . Polyclinical. Hospital in Torun. . Definition. . symptom not a . disease. . too. . low. . glucose. Gluconeogenesis continued…………………... Class name – IVH. Course name - ZOO-Biochemistry. (Rohit). Overview of Gluconeogenesis. First step (. Conversion of Pyruvate to Phosphoenolpyruvate. FATE OF . PYRUVATE. MADE FROM GLYCOLYSIS. FATE OF . PYRUVATE. MADE FROM GLYCOLYSIS. Lactic . acid fermentation occurs in muscle cells when oxygen is in low . supply.. Human Lactate . dehydrogenase . 1. FORWARD REACTION. REVERSE REACTION. D. G. o . (kJ). K. Significance. 200. 100. 50. 10. 1. 0. -1. -10. -50. -100. -200. 9x10. -36. 3x10. -18. 2x10. -9. 2x10. -2. 7x10. -1. 1. 1.5. 5x10. 1. 6x10. 8. Learning Goal . Describe how glucose is synthesized from . noncarbohydrate. molecules.. Glucose is synthesized in the tissues of the liver and kidneys. . Tissues . that use glucose as their main energy source are the brain, skeletal muscles, and red blood cells.. &. The Pentose Phosphate Pathway. Dr. . Shaimaa. . Munther. . Glycogen Metabolism. A constant source of blood glucose is an absolute requirement for human life. Glucose is the greatly preferred energy source for the brain, and the required energy source for RBC and muscle, since it’s the substrate for anaerobic .