PPT-Identification of mutations prognostic of relapse after all

P Ferguson L Quek M Metzner I Ahmed C Garnett S Jeffries K Piechocki R Danby M Raghavan A Peniket M Griffiths A Bacon J Ward K Wheatley P Vyas C Craddock Introduction. Somatic Mutations . in Follicular Lymphoma. Michael R. Green, Andrew Gentles, Ramesh Nair, Jonathan Irish, . Ron Levy, Ash . Alizadeh. .. Follicular Lymphoma (FL). B Cells. (follicular structures). T . Apoptosis. Differentiation. Asymptomatic,IPSS. low . Low/Int-1. Symptomatic,IPSS. Int-2/High Risk. BM function. Greenberg, Blood 1997, . Malcovati,JCO. 2009,Greenberg . Blood 2012. Transfusion. Transfusio. Foundations. of Addictions Counseling. ,. 3e. Capuzzi. & Stauffer. Copyright © 2016, 2012, 2008 . by Pearson Education, Inc.. All Rights Reserved. Relapse: Return of disease after full or partial recovery. What is Relapse Prevention?. A method of teaching recovering students to recognize and manage relapse warning signs. . Becomes a primary focus for students who are unable to maintain abstinence from alcohol or drugs despite primary treatment.. What is Relapse Prevention?. A method of teaching recovering students to recognize and manage relapse warning signs. . Becomes a primary focus for students who are unable to maintain abstinence from alcohol or drugs despite primary treatment.. Point mutations. single base change . silent mutation. no amino acid change. redundancy in code. missense. change amino acid. Changes the final protien. nonsense. change to stop codon. Stopping prematurely . The sequence of bases in DNA are like the letters of a coded message or even the letters of a simple alphabet. . If we change the sequence of the letters do we change the nature of the message?. That . Understand how they occur. Analyze the different types of mutations. Understand how mutations affect amino acid sequences and proteins. Objective. Central Dogma. DNA is transcribed into RNA, RNA is translated into proteins. Small-scale mutations. Missense mutations. Nonsense mutations. Silent mutations. Frameshift mutations. Large scale mutations. Causes. Mutagens. The results of mutation. Mutations. Genetic mutations are changes in the DNA sequence, caused by various mechanisms.. Advances in AML. Doses of . Dano. , . Cladrabine. Azacytidine. GO. CPX. Midostuarin. , flt3 inhibitors. IDH inhibitors. BCL-2 inhibitors. Genomic Classification and Prognosis in Acute Myeloid . Leukemia. myeloid leukemia. Jacqueline Cloos. Pediatric. . Oncology. /. Hematology. and . Hematology. Acute leukemia. 2. Acute . myeloid. leukemia. ALL. AML. Acute . lymphoblastic. . leukemia. Normal bone marrow. Rhabdomyosarcoma. . OBJECTIVES: . To . evaluate relapse patterns in . rhabdomyosarcoma. (RMS) patients after radiotherapy (RT. ). .. Serra . Kamer. ¹. , . Meltem . Öztürk. ¹. , . Eda . Ataseven. Niels Peek. Professor of Health Informatics. The University of Manchester. Clinical prediction methods. CAVEAT . . Why do we need prognostic models? Prevention is more effective than cure. ischemia. Reporter: R4 . 張妙而. Introduction. . Mutations in . nucleophosmin. . 1 (. NPM1. ) . gene, one . of the most . common gene . mutations . . . (. 25%-30%) in . AML. NPM1. mut. . co-occurs with .