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Cells Interact with their Environment: Cells Interact with their Environment:

Cells Interact with their Environment: - PowerPoint Presentation

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Uploaded On 2016-04-11

Cells Interact with their Environment: - PPT Presentation

The Extracellular Matrix What is the extracellular matrix Extra E cellular C matrix M Outsideouter of the cell surroundings within which something is contained The part of animal tissue outside of the cells that provides ID: 278649

cells cell matrix ch2 cell cells ch2 matrix ecm polymer structure monomer species contained units glucosamine synthetic biomaterial polymers

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Presentation Transcript

Slide1

Cells Interact with their Environment:The Extracellular MatrixSlide2

What is the extracellular matrix?

Extra (E) cellular (C) matrix (M)

Outside/outer of the cell surroundings within which something is contained

The part of animal tissue (outside of the cells) that provides

__________________________ to the cells contained within.

What is the ECM composed of?

_____________________: large polysaccharides with net negative

charge, attracting __________ ions, such as ______, which then

cause ___________ accumulation, _______________________

_________: collagen &

elastin

, which provide ______________

Cell adhesion proteins:

fibronectin

, which provides anchor points for

cells to ____________ to.Slide3

Cell Interaction with the ECM (Migration)

Steps:

1. Protrusion

2. Adhesion

3. Contraction

4. ReleaseSlide4

How might a scientist study cell-ECMinteractions?

What characteristics might a synthetic ECM need

What materials might have

these desired qualities?Slide5

What is a polymer?

Poly -

mer

-

Definition: polymers are long-chain molecules consisting of repeating units (called: ______________) which are typically connected by ___________ chemical bonds.

Synthetic

Example Polyethylene (PE): CH2=CH2

CH2

(CH2CH2)n

Natural

Example polysaccharide:

Chitosan

, randomly distributed D-glucosamine and N-acetyl-D-glucosamine unitsSlide6

Characterization of Polymers

Skeletal structure:

Primary structure:

Homopolymer (1 monomer species)

–A-A-A-A-A-A-

Copolymer (2 or more monomer species)

Random –A-B-A-A-B-A-B

Block –A-A-A-B-B-B-

Alternating –A-B-A-B-A-B

Linear

Branched

Free

CrosslinkedSlide7

Polymer Usage as a Biomaterial

What is a biomaterial?

Examples:Slide8

Carbon Ring Numbering