The Extracellular Matrix What is the extracellular matrix Extra E cellular C matrix M Outsideouter of the cell surroundings within which something is contained The part of animal tissue outside of the cells that provides ID: 278649
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Slide1
Cells Interact with their Environment:The Extracellular MatrixSlide2
What is the extracellular matrix?
Extra (E) cellular (C) matrix (M)
Outside/outer of the cell surroundings within which something is contained
The part of animal tissue (outside of the cells) that provides
__________________________ to the cells contained within.
What is the ECM composed of?
_____________________: large polysaccharides with net negative
charge, attracting __________ ions, such as ______, which then
cause ___________ accumulation, _______________________
_________: collagen &
elastin
, which provide ______________
Cell adhesion proteins:
fibronectin
, which provides anchor points for
cells to ____________ to.Slide3
Cell Interaction with the ECM (Migration)
Steps:
1. Protrusion
2. Adhesion
3. Contraction
4. ReleaseSlide4
How might a scientist study cell-ECMinteractions?
What characteristics might a synthetic ECM need
What materials might have
these desired qualities?Slide5
What is a polymer?
Poly -
mer
-
Definition: polymers are long-chain molecules consisting of repeating units (called: ______________) which are typically connected by ___________ chemical bonds.
Synthetic
Example Polyethylene (PE): CH2=CH2
CH2
(CH2CH2)n
Natural
Example polysaccharide:
Chitosan
, randomly distributed D-glucosamine and N-acetyl-D-glucosamine unitsSlide6
Characterization of Polymers
Skeletal structure:
Primary structure:
Homopolymer (1 monomer species)
–A-A-A-A-A-A-
Copolymer (2 or more monomer species)
Random –A-B-A-A-B-A-B
Block –A-A-A-B-B-B-
Alternating –A-B-A-B-A-B
Linear
Branched
Free
CrosslinkedSlide7
Polymer Usage as a Biomaterial
What is a biomaterial?
Examples:Slide8
Carbon Ring Numbering