PPT-Genetic plasma cell signatures in high-risk smoldering myel

Presented By Sham Mailankody at 2016 ASCO Annual Meeting Massive genetic heterogeneity in ltbr gtmultiple myeloma Presented By Sham Mailankody at 2016 ASCO Annual Meeting Multiple myeloma consistently preceded by precursor states. T: J. Ohlemiller Introduction Smoldering is a slow, low-temperature, flameless form of combustion, sustained by the heat evolved when oxygen directly attacks the surface of a condensed-phase fuel. Sm -. Gateway to the Cell. 2. Photograph of a Cell Membrane. 3. Cell Membrane. The cell membrane is . flexible. and allows a . unicellular. organism to . move. 4. Homeostasis. Balanced. internal condition of cells. Common (West), low-grade B-cell lymphoma. Affects elderly. Arises from germinal center B-cell. Lymphoma cells have specific translocation t(14:18), in which Bcl2 gene on chr18 fuses with . IgH. gene on chr14, causing . ICP-MS. Stuart Morrow. June 12, 2015. Technique Overview. ICP-MS . is a sensitive instrumental technique used for elemental analysis . Different than traditional MS . No information on MW or . structure. Smoldering Myeloma: To Treat or not to Treat Ruben Niesvizky MD Myeloma Center Myelomacenter.org run9001@med.cornell.edu CASE A 47-year-old man is diagnosed with smoldering multiple myeloma . He has Jamie . Winternitz. Institute of Botany and Vertebrate Biology, Czech Academy of Sciences. Outline of talk. The Chimp and the River. Negative-frequency dependent selection. Phylogenetic methods. The Island Fox. Pulmonary . Hypertension. Gregory Kato, MD. Sickle Cell Center of Excellence. Department of Medicine, Division of Hematology-Oncology. Heart, Lung and Blood Vascular Medicine Institute. University of . What is the plasma membrane?. A flexible boundary between the cell and its environment which maintains . HOMEOSTASIS. within the cell. **Remember that . HOMEOSTASIS. is a state of balance/equilibrium within the cell.. Interstitial space (rectangle). Blood Plasma (red line). The three compartments will maintain equilibrium [but the cell should have the largest amount of fluid]. Fluid will shift based on:. . Na. Khodabande. Farabi Eye Hospital. TUMS. Modifiable RFs ?. Genetic bases?. Genetic testing, to do or not to do?. Risk Score?. Risk Factors. Development. Progression. Non-Modifiable RFs. Age. The . number one. Presented by. Dr . Sanjoy. Deka. PLASMA MEMBRANE OR CELLMEMBRANE. Points to be discussed…. Nature of plasma membrane. Movement of substances across plasma membrane. Diffusion and osmosis. Hypotonic, isotonic and hypertonic solution. Myeloma Symposium 9/29/2018. Aric Hall, MD – Assistant Professor – UW School of Medicine & Public Health. Disclosures. I have no significant conflicts of interest to disclose. . I have no financial relationship with any institution profiting from pharmaceutical sales, diagnostic testing, or any type of medical technology. . Risk stratification and Therapeutic Options. Natalie S. Callander, M.D.. University of Wisconsin Carbone Cancer Center. 1. MGUS definition. 2. Factors associated with MGUS progression. 3. Appropriate evaluation. Aric Hall, MD. Assistant Professor – UW Health. Objectives . To discuss pathophysiology of plasma cell disorders. To define and describe the asymptomatic plasma cell dyscrasias. To discuss prognosis.