Faculty David I. Bernstein, MD Professor of

Transcript:Faculty David I. Bernstein, MD Professor of:
Faculty David I. Bernstein, MD Professor of Medicine and Environmental Health Division of Immunology, Allergy and Rheumatology University of Cincinnati College of Medicine Cincinnati, Ohio Amy S. Paller, MD Walter J. Hamlin Professor and Chair of Dermatology Professor of Pediatrics Northwestern University Feinberg School of Medicine Chicago, Illinois Program Overview Video 1. Epidemiology Video 2. Pathophysiology Video 3. Clinical Assessment Video 4. Medical Management: Overview Video 5. Medical Management 1 Video 6. Medical Management 2 Video 7. Prevention of Flares Video 8. Emerging Therapies Learning Objectives After participating in this program, the participant will be able to: Examine the epidemiology and pathogenesis of AD and the relevance to the management of patients with AD . Integrate a proactive approach to long-term disease management in AD, with a focus on prevention of flares, assessment of disease activity, and patient education. Discuss the mechanisms, efficacy, and safety data for emerging biologic therapies and which patients are likely to benefit. Epidemiology Video 1 Atopic Dermatitis: Definition Chronic, pruritic, eczematous skin disease1,2 Often associated with elevated serum IgE levels and a personal or family history of type I allergies, allergic rhinitis, and asthma Atopic dermatitis = atopic eczema1 Atopic dermatitis ≠ eczema ICD codes for atopic dermatitis and eczema are different 1. Eichenfield LF, et al. J Am Acad Dermatol. 2014;70(2):338-351. 2. Whiteley J, et al. Curr Med Res Opin. 2016;doi:10.1080/03007995.2016.1195733. Case Scenario: Emily HPI: Emily is being seen for her 6-month well-child visit Red cheeks with edema and exudation Emily has dry skin with generalized itching, sometimes making it difficult for her to fall asleep Medications: none Allergies: dairy products aggravate skin itching and rash FH: father and mother with seasonal allergic rhinitis PE: skin – facial eczema, xerosis of face, as well extensor surfaces of joints Atopic Dermatitis: Epidemiology Occurs most frequently in children, but also affects adults1,2 Up to 25% of children Up to 7% of adults Prevalence higher in women than men2,3 Onset commonly between ages of 3 and 6 months1,2 60% by age 1 year 85% to 90% by age 5 years 1. Eichenfield LF, et al. J Am Acad Dermatol. 2014;70(2):338-351. 2. Guttman-Yassky E, et al. J Allergy Clin Immunol. 2011;127(5):1110-1118. 3. Whiteley J, et al. Curr Med Res Opin. 2016;doi:10.1080/03007995.2016.1195733. Atopic Dermatitis: Epidemiology (cont) Severity1 In children Mild (two-thirds), moderate (one-quarter); severe (<10%) Percentage of people with severe AD increases with age Pooled analysis of 45 studies