Superior Mediastinal Syndrome Saadiq Moolla 04 October 2023 Superior mediastinal syndrome A group of disorders characterised by infiltration, entrapment or compression of mediastinal structures Trachea Oesophagus SVCgreat vessels Zardi.
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Superior Mediastinal Syndrome Saadiq Moolla 04 October 2023<br>
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Superior mediastinal syndrome A group of disorders characterised by infiltration, entrapment or compression of mediastinal structures
Trachea
Oesophagus
SVC/great vessels Zardi. Exp Ther Med. 2016.<br>
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Collateral circulation 4 potential collateral pathways:
Azygos-hemiazygos pathway (via intercostal and lumbar veins)
Internal thoracic route (via epigastric and superficial thoracic veins)
Lateral thoracic route (via superficial circumflex, long saphenous and femoral veins)
Vertebral and paravertebral route
Blockages proximal to SVC: blood returns to SVC via azygos vein
Blockages at or distal to SVC: retrograde flow through azygos vein and collaterals to IVC Shah. Cureus. 2023.<br>
Diagnostic approach Imaging:
CXR
CT/MRI
Doppler ultrasound if thrombus suspected
Venography – usually for surgical planning
Tissue for Histology<br>
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Kishi Scoring system Straka. SpringerPlus. 2016.<br>
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Grading system for SVC syndrome Yu. J Thorac Oncol. 2008.<br>
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Treatment options General measures:
Head elevation
Glucocorticoids can be effective in 2 settings:
Steroid-sensitive malignancies such as lymphoma and thymoma
Prophylaxis for radiation-induced oedema
High dose, limited duration and not as primary therapy
Loop diuretics: no evidence of efficacy, now criticised
Radiation therapy: up to 80% efficacy in lung cancer
Chemotherapy: suitable alone for certain cancers, namely SCLC, lymphoma and germ cell tumours
Surgery: bypass graft
Endovascular therapy: over 90% efficacy
Antibiotics or anticoagulation in non-malignant causes Patriarcheas. Cureus. 2022; Straka. SpringerPlus. 2016.<br>
