PPT-The Chromatin and genome packaging

Dr Karzan Mohammad Chromatin Eukaryotic DNA is closely associated with proteins creating chromatin Of two types Heterochromatin Euchromatin Chromatin Euchromatin Actively transcribed. 32 Packaging Innovations and Luxury Packaging London returns to the Business Design Centre on 30 September and 1 October 2014 and welcomes its strongest ever exhibitor line up Luxury exhibitor Leo Luxe will undoubtedly make your packaging light up with Denovo genome Denovo genome outline outline novogenome from contigs from assembled contigs annotation Denovo genome Denovo genome Reads contig Gene Gene Annotation Gene Annotation Forgene February . 27 2013. Fundamental Goals. Improve comprehensiveness and accuracy of gene annotation. Define novel protein coding and . noncoding. gene products, including variants. Define . noncoding. regulatory elements, including both sequence and epigenetic features. integrated encyclopedia of DNA elements in the human . genome”. ENCODE Project Consortium. . Nature . 2012 Sep 6; 489:57-74.. Michael . M. Hoffman. University of Washington. 12 September 2012. Major results. On the immortality of television sets: “function” in the human genome according to the evolution-free gospel of ENCODE. AKA:. why the ENCODE . project is full of it. by Matthew . Oberhardt. What is ENCODE?. interactions. Exploring transcription factor binding and the . epigenomic. landscape. Lisa Stubbs. Eukaryotic genomes . are. complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins. interactions. Exploring transcription factor binding and the . epigenomic. landscape. Lisa Stubbs. Eukaryotic genomes . are. complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins. interactions. Exploring transcription factor binding and the . epigenomic. landscape. Lisa Stubbs. Eukaryotic genomes . are. complex structures comprised of modified and unmodified DNA, RNA and many types of interacting proteins. Features: . (. i. ) Provides standardised ‘. DeepSEA. score’ for noncoding variants. (ii) Provides info on chromatin feature(s) and cell type(s) to concentrate on. (iii) Identify base-resolution sequence features by . Introduction. Genetic . material DNA. . in . . eukaryotic . cells never . found as a naked molecule but always found in association . with:. i. . . Histon. . proteins. , . i. i. HMG . proteins. ,. Chromatin-binding factorshistone macromolecules that bind either directly or indirectly to DNA.Transcription factorhistone protein that directly binds to DNA.Architectural proteinsProteins that have a Hardison. Genomics5_1. 2/17/15. 1. Types of data in genomics. Protein and DNA sequences . Protein structure and function. Comparisons of DNA and protein sequences. Between species. Among individuals within a species. . phase. . separation. (LLPS) under . physiologic. . conditions. Linker. DNA . length. and . patterning. , . histone. H1, and . acetylation. modulate . chromatin. LLPS. Acetylated. . chromatin.