PPT-Abdominal Pain, Jaundice & Abnormal Liver Function Tests

An 8yearold boy presents with three days history of abdominal pain lasting 20 min It occurs before breakfast amp sometimes at school where it will generally pass when he busies himself with activities He has a tendency to constipation His pains worsen when faced with tests at school or other stressors Exam is normal. -it depend on the severity and whether it is acute or chronic. Acute liver failure:-. Duo to :-. 1-viral hepatitis. 2-drug reactions, halothane, INH, NSAIDs. 3-paracetamol overdose. 4-mushroom poisoning. John F. Pohl MD. Professor of Pediatrics. Primary Children’s Medical Center. University of Utah. Salt Lake City, Utah. Disclosure: INSPPIRE to Study Acute Recurrent and Chronic Pancreatitis in Children, NIH R21 Grant, NIDDK. By the end . lecture we will be able . 1.To know what is normal liver and Spleen .. 2. To know about various causes of hepatosplenomegaly.. 3.How to do the clinical examination of the patients.. 4. How will we do the workup of the patients.. John F. Pohl MD. Professor of Pediatrics. Primary Children’s Medical Center. University of Utah. Salt Lake City, Utah. Disclosure: INSPPIRE to Study Acute Recurrent and Chronic Pancreatitis in Children, NIH R21 Grant, NIDDK. Gastroenterology and Endoscopy. Colonoscopy, . Crohns. disease, ulcerative colitis, coeliac disease and IBS. Clinical Teaching . -Clinical senior lecturer Deakin University. -Director of National training in capsule endoscopy (small intestine). Measurement of Serum Bilirubin (Total, direct &indirect) . T.A. Bahiya Osrah. Bilirubin. Bilirubin. is the product of . heme. degradation (80% hemoglobin, 20% other . hemo. -protein as . cytochrome. ALT&AST . T.A. Bahiya M. Osrah. Liver Functions. The liver is in the upper right part of the abdomen. . The functions of the liver include: . 1-storing glycogen (fuel for the body) which is made from sugars. . . . Shaimaa. . Munther. . Basic Anatomy. • liver unequally divided. into 2 lobes. • it has a dual blood supply. – Portal vein. – Hepatic artery. It has an excretory system for bile excretion. Dr.S.Parthasarathy. . MD DA . DNB. PhD FICA IDRA . Anatomy . Functions of liver . The liver is vital for. protein synthesis. glucose homeostasis . . bilirubin. excretion . toxin removal . Rob Grogan . rjg17@ic.ac.uk. . Year 4 BSc Anaesthesia & Crit Care. Disclaimer & sponsor . “. MedED. does not represent the ICSM Faculty or Student Union. This lecture series has been designed and produced by students. We have made every effort to ensure that the information contained is accurate and in line with Learning Objectives featured on SOFIA, however, this guide should not be used to replace formal ICSM teaching and educational materials.”. Dr. Muntadher Abdulkareem Abdullah. M.B.Ch.B,CABM,FIBMS,FIBMS(GE.&HEP.). At the end of this lecture , you must be able to answer these questions. Q1:. 22 year old male patient , with history of recurrent self resolving jaundice since childhood, presented with jaundice at the end of heavy duty day , otherwise the patient is healthy with nonsignificant other finding,. Dr Heather Lewis. Consultant . Hepatologist. . Imperial College Healthcare NHS Trust. The Lancet 2014. Mortality from liver disease in the UK. Liver function tests . vs. liver blood tests. Bilirubin, albumin and INR are the only blood markers of liver function. Each organ of the body has to perform its biochemical functions. Possible only when the cells of the organ are intact in structure and function. Any abnormality in the tissue caused by exogenous or endogenous factors will seriously impair the organ function which influences the health of the organism. . Laboratory investigations. ESR: . increased: inflammation, tumors . (but can be normal). Blood count . leukocytes: . : inflammation. eosinophilia: helminthiasis, allergy. anemia (Hb, HCT): .