PPT-HKS Tumore HKS Tumore Epigenetics in glioma

MGMT ABCB1 and ABCG2 methylation in glioma Moritz C Oberstadt PhD Tumor diseases High maligne tumors with low 5 years overall survival OS Brain tumors 1315 Stomach 1213. :. DNA . methylation. II. DNA . methylation. in plants (Ch9). Differences between plants and animals. Auxotroph . vs. . heterotroph. Sessile . vs. . mobile. Motionless and rigid . vs. . migrating and flexible cells. the process by which a trait/gene changes function; the gene has been . co-opted to do a new job. Gene Co-option. Inheritance of Acquired Characteristics. Epigenetics turns on/off genes. http://cnx.org/content/m26565/latest/graphics35.jpg. . Cancer Immunotherapy. Immunity and Tumors. 1890s. Coley. treats patients with bacterial extracts. . 1950-1960s. Burnet and Thomas. - Immune-surveillance Hypothesis. “. Major function of the immune system is to recognize and destroy arising malignantly transformed cells. -What is epigenetics? -Epigenetics and us -Past, present, and future You Are What Your Mother Ate:What is Epigenetics?Daniel Lieber DNA is the Source of Heritable Information in the Cell organism Crea MACROECONOMIC INTERDEPENDENCE. (I) Interdependence: . Y. depends on . Y*.. (II) The two-country model, to be used for . a country big enough to affect world income . Y*.. Simultaneous determination of . How do we make this work?. Dr. Paul S. Anderson. NYANP. 2017. (c) PS Anderson - www.ConsultDrA.com - 2017. 1. Dr. Anderson - Disclosures. Ownership interest in:. • Advanced Medical Therapies Clinic Seattle, WA. Joo. ’ Kim. Louisiana State University. What is . Epigenetics. ?. “the study of mitotically and/or . meiotically. heritable changes in gene function that can not be explained . by changes . in DNA sequences” – (Riggs et al. 1996). . O. rigin. Occult Metastases. BIOLOGIA delle METASTASI. Prof. S. Berretta – Lezioni Clin. Chirurgica 2002. METASTATIC CASCADE. “ THE HALLMARK of MALIGNANT TUMOUR”. . Capacità e potenzialità di dare metastasi. http://www.knowabouthealth.com/wp-content/uploads/2010/06/mcdonalds_.jpg. http://emilyscarenhealth.wordpress.com/2011/10/04/attention-a-must-read-for-smokers/. Can “. nuture. ” change “nature” ?. Epigenetics comprises (hereditary) changes in gene expression without altering the DNA sequence . Epigenetics is a biological subdiscipline that deals with questions of development, heredity, gene regulation and evolution .  . Project . Promoter: University of Tartu. Project . Leader: . Tambet Teesalu . PhD, Visiting Professor.  . Project Partner: University of Bergen. Research Group Leader: . Rolf Bjerkvig. , PhD, Professor. A . Multi-Level Partnership with the Office of Career . Advancement. Keely Wilczek, Manager of User Services & Engagement, HKS Library & Knowledge Services (LKS). Beth Olson, Associate Director & Career Coach, . Glioma (LGG) Stephanie Rice, BS (MSIV), Abigail T. Berman, MD Michelle Alonso - Basanta , MD, PhD University of Pennsylvania October 2013 Updated by Elizabeth J. Buss, MD and Tony J. C. Wang, MD Colum county-level socioeconomic measures. Jill S. Barnholtz-Sloan, PhD. Sally S Morley Designated Professor in Brain Tumor Research. Associate Director for Bioinformatics and Translational Informatics. Case Western Reserve University School of Medicine.