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partial chromosome sets - PDF document

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partial chromosome sets - PPT Presentation

evolutionpolyploidization cause polyploidy Egx0000a 2 sperm 1 egg 3Nb Failure of anaphase occur chromosomalabnormalities or aberrations not strictly applicable because sometimes ID: 940298

chromosome gene crossing arise gene chromosome arise crossing occur x0000 position sequences dna repeats duplicated genes deletions intrachromosomal called

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(partial chromosome sets). evolutionpolyploidization cause polyploidy. E.g.:�(a) 2 sperm + 1 egg --

3N(b) Failure of anaphase occur), chromosomalabnormalities or aberrations (not strictly applicable becaus

e sometimes ! 2different structures are present in population in high frequency; can't say thateither one i

s aberrant or ab 1 2 2 10¥ Duplicative transposable elements can spread in genome even if they are mild

ly transcriptasemakes DNA copy of the RNA, and DNA is integrated into target sequence.The act of transposit

ion itself may cause rearrangements of adjacent sequences.TE inserted in gene or in controlling sequences c

an make gene inactive, just like amutation.If transposon excises cleanly, gene activity can be restored.The

copies of a transposable element are sites of homology at which crossing-over can occur within a chromosom

e and between homologous or the bane of DNA sequencers; this is why a large part of the humangenome still h

asnÕt been sequenced.(3) Longer repeated sequences arise 5 4 5 6Might be called dup45(1) Duplications ca

n arise by duplicative transposition.(2) Duplications can occur via processed pseudogenes:(3) Duplication c

an occur via unequal crossing-over between existing repeats, usually in sisterchromatids produced by replic

ation of a chromosome. clustered multigene family.!alpha A# 'b1 detail from a single anc

estral gene. That gene duplicated to givemyoglobin and globin genes; the latter duplicated to form ! and

�--deletion-- 1 2 3 6 Might be called def45.Origins of deletions:Intrachromosomal crossin

g-over between direct repeats:5. Inversions arise by intrachromosomal crossing-over between invertedrepeat

s.Inversions arise 3 4 r 5 6 7 8 r 9 10 --reciprocal �translocation-- 1 2 3 4 r 9 10 7 8

r 5 67. Robertsonian fusions change N.Small arms are lost.Extreme example of change in chromosome number is

seen in deer. Reeve'smuntjac 2N Position effect = phenotype of a gene or region of a chromosome depends

on itsneighbors. One obvious rationale: move gene to different position, may put under controlof differen

t he physical map to the genetic map by using overlapping deletions.From these data, can't tell whether d

is 5, 6, or both. But we know it can't be bothif d is a point mutation.Order, and sometimes the position,