PPT-Quantifying (missing) heritability for

common disease AKA everything is much harder in a binary trait Naomi Wray 1 Missing heritability psychiatric disorders N cases N loci h 2 SNPh 2 Schizophrenia 67K 245 80 26. RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener Chapters 6, 7, and 8. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. Personality. Nature . v. . Nurture. Nature!. “They are born that way!”. Responsible for ~50% of personality. Nurture!. “It’s their experiences & how they were raised!”. Responsible for ~50% of personality. Quantifying. . Metadata. . Quality. Werner Bailer . | . Europeana. AGM 2015. The Problem. Metadata. . from. . many. . sources. Heterogeneous. . formats. . (. and. . thus. . conversions. ). Different . New Statistical Approaches. Or . Zuk. . Broad Institute of MIT and Harvard. orzuk@broadinsitute.org. www.broadinstitute.org/~orzuk. Genome . Wide Association Studies (GWAS). 2. l. ength: ~3x10. 9. ACCGAGAGGGTT. Sciences: QUICK EXAMPLES. #. konfoundit. Kenneth A. . Frank. Ran . Xu; Zixi . Chen. ; I-Chien Chen, Guan Saw. 2018. (. AERA on-line video – cost is . $105. ). Motivation . Statistical inferences are often challenged because of uncontrolled bias. There may be bias due to uncontrolled confounding . Sciences: QUICK EXAMPLES. #. konfoundit. Kenneth A. . Frank. Ran . Xu; Zixi . Chen. ; I-Chien Chen, Guan Saw. 2018. (. AERA on-line video – cost is . $105. ). Motivation . Statistical inferences are often challenged because of uncontrolled bias. There may be bias due to uncontrolled confounding . . SYFTET. Göteborgs universitet ska skapa en modern, lättanvänd och . effektiv webbmiljö med fokus på användarnas förväntningar.. 1. ETT UNIVERSITET – EN GEMENSAM WEBB. Innehåll som är intressant för de prioriterade målgrupperna samlas på ett ställe till exempel:. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. Genes and Inheritance. 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Course Outline. 1. Genes and Inheritance (GG). 2. Molecular Biology of the Genome (JL). 3. . Population and Evolutionary Genetics (JL). heritability. (“GWAS and heritability”). peter.visscher@uq.edu.au. 1. The original definition of ‘missing heritability’. NB both are estimates that can be biased (up or down).  . 2. My 2009 presentation. Learn all genetic traits!!!!. Objectives. Compare and contrast the idea of genetics . vs. environment. List examples of high and low heritability estimates. Define expected progeny differences. Describe the importance of livestock improvement. Loic Yengo, PhD. Institute for Molecular Bioscience. The University of Queensland. l.yengo@imb.uq.edu.au. 1. What quantitative genetics tells us about heritability?. Part 1. 2. Outline. Definition of heritability (and genetic correlation). Associate . Professor. Dept. of Genetics and Animal Breeding. PSTU, . Barishal. campus. Overview. Definition. Scale of Heritability. Example. Uses of Heritability. Limitations of Heritability. Methods of Estimation of Heritability.