PPT-Quantifying (missing) heritability for

common disease AKA everything is much harder in a binary trait Naomi Wray 1 Missing heritability psychiatric disorders N cases N loci h 2 SNPh 2 Schizophrenia 67K 245 80 26. RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener 1. ) A bit of basics. 2) Heritability (Ch 10). 3) Assortative mating (Ch 10). 4) Homework. 5) Questions, thoughts?. A bit of basics. Mean:. μ. x. = . Σ. x. i. / N. = (1+2+2+3+3+4) / 6 = 15/6 = 2.5. Lipika. Ray. 4th . June 2010. Heritability:. Phenotype (P) = genotype (G) + environmental factors (E). (observed) (unobserved) (unobserved). Variances:. Heritability is defined as ratio of variances, by expressing the proportion of the phenotypic variance that can be attributed to variance of genotypic values:. RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener Chapters 6, 7, and 8. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. 3. rd. -Cycle . Pollen Mix Tests. Andrew Sims. Introduction. Pollen Mix (PMX) trials. 4 Coastal Series, 3 Piedmont Series. 51 total sites. Objectives. Estimate Breeding Values . Include large number of genetic entries. New Statistical Approaches. Or . Zuk. . Broad Institute of MIT and Harvard. orzuk@broadinsitute.org. www.broadinstitute.org/~orzuk. Genome . Wide Association Studies (GWAS). 2. l. ength: ~3x10. 9. ACCGAGAGGGTT. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. Genes and Inheritance. 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Course Outline. 1. Genes and Inheritance (GG). 2. Molecular Biology of the Genome (JL). 3. . Population and Evolutionary Genetics (JL). Naomi Wray. 2016 Module 18: . Statistical & Quantitative Genetics of Disease. 1. Aims of Lecture 1. If a disease affects 1% of the population and has heritability 80%. We will show why . these statements are . heritability. (“GWAS and heritability”). peter.visscher@uq.edu.au. 1. The original definition of ‘missing heritability’. NB both are estimates that can be biased (up or down).  . 2. My 2009 presentation. Naomi Wray. 2016 Module 18: . Statistical & Quantitative Genetics of Disease. 1. Misunderstandings in MZ twins. “Estimates of heritability of liability to a number of diseases turned out to be quite high. This was a surprise to those not versed in quantitative genetics who tended to think that low concordances rates in MZ twins implied low heritability.” Fraser (1976) . Associate . Professor. Dept. of Genetics and Animal Breeding. PSTU, . Barishal. campus. Overview. Definition. Scale of Heritability. Example. Uses of Heritability. Limitations of Heritability. Methods of Estimation of Heritability. Associate Professor. Dept. of Genetics and Animal Breeding. PSTU, Barishal Campus. Repeatability. . Important repeated traits are. :. Milk production, egg production, number of offspring of goat in different litters..