PPT-L’exploration du métabolisme des acides aminés

4 eme année pharmacie Dr MorsliM P lan Introduction Structure des acides amines Métabolisme des acides aminés Les pathologies du métabolisme des acides amines Exploration des pathologies du métabolisme des acides amines . Chehimi Iluminada Gallardo Jean Pinson and Neus Vila Departament de Qu mica Universitat Auto noma de Barcelona Bellaterra Espan a ITODYS Universite Paris 7Denis Diderot 75005 Paris France and Laboratoire dElectrochimie Mole culaire Universite Paris Histamine. Amines. Amides. Amino acid. P. eptides. Comparison of NH. 3. to Amines . 15.1 Amines. pyramidal. VSEPR?. Classification of Amines. Amines are classified by the number of carbons directly bonded to the nitrogen atom: . The painkiller morphine is obtained from opium, the dried sap of unripe seeps of the poppy . P. apaver. . somniferum. Amines are relatives of ammonia and are usually classified as primary, secondary or tertiary. Amine nomenclature. diisopropylamine. pyrrole. nicotine. histamine. pyrrolidine. Formation of amines. triethylamine. Mechanism for LAH reduction of amides. 1-methylpiperidine. One equivalent . SN2 is faster the more R groups on N. 1. Amines and Amides both contain nitrogen (N).. . 2. Amines and Amides. Classified . as . primary. , . secondary. , or . tertiary. based on the number of alkyl groups attached to the nitrogen atom.. These end in –amine. There is, however, rather confusingly two ways of using this suffix. The exam board tend to use the common version where the name stem ends in -. yl. . propylamine. . . If there is another priority functional group as well as the amine group then the prefix amino is used.. A heterocyclic amine is a cyclic organic compound that consists of a ring of five or six atoms, of which one or two are nitrogen atoms.. The aroma of pepper is due to . piperidine. , a heterocyclic amine. Présenté par: Dr. A. Saleh. Elimination indirecte après biotransformation. Elimination directe par excrétion rénale ou biliaire. Métabolisme.  . Que devient le médicament dans l’organisme ?. Présenté par: Dr. A. Saleh. Elimination indirecte après biotransformation. Elimination directe par excrétion rénale ou biliaire. Métabolisme.  . Que devient le médicament dans l’organisme ?. Brønsted. and Lewis bases. Amines are basic because they possess a pair of unshared electron create an electron density around the nitrogen atom.. Amine are more basic than water and less basic than hydroxide ion:. * up to 8 carbon atoms in the main chain, with sides chains limited to a maximum of 2 carbon atoms. * one or more amine groups. Amines contain one or more amino functional group (-NH. 2. ). Naming amines follows the alkane naming conventions, adding ‘amine’ as the suffix.. 3. . Amines can be classified as primary, secondary or tertiary. . Primary amines . have one carbon attached to the nitrogen atom of the amine group. . Secondary amines . have two carbons attached to the nitrogen atom of the amine functional group. . Classification of amines. Nomenclature of amines. Physical Properties of amines. Preparation of amines. Reaction of amines. 2. By the end of this chapter the student . will know:. Learning. . Objectives. 1. objectives:. Fundamental concepts on basic character of amines.. Applications of these concepts in comparing the relative basic strengths of NH. 3. , various alkyl amines, C. 6. H. 5. NH. 2. and other substituted aromatic amines..