HYPERLIPIDEMIA WITH HYPERTENSION Scenario Here is a 5o years old female patient hospitalized for four days Chief complaints co chest pain since 2 hours History of present illness ID: 934343
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Slide1
THERAPEUTICS -1
CASE PRESENTATION
Slide2HYPERLIPIDEMIA WITH HYPERTENSION
Slide3Scenario:
Here is a 5o years old female patient hospitalized for four days.
Chief complaints:
c/o chest pain since 2 hours.
History of present illness:
The patient was apparently alright 2 hours back but developed chest pain, which is non radiating, not associated with sweating
.
Past medical history:
k/c/o hypertension since 2 years
.
Slide4Personal history:
Smoking for past 15 years
.
Family history:
Father- MI
LABORATORY DATA: LIPID PROFILE:
DATE
B.P.
P.R.1|3150/100902|3140/90783|3140/80744|3120/8076
Cholestetrol
254
VLDL
64.6
LDL
157
TGS
323
Slide5SOAP NOTE
SUBJECTIVE:
Here is a female patient present with complaint of chest pain since 2 hours.
OBJECTIVE:
BP- increased- due to hypertension
.
CHOLESTEROL- INCREASED
VLDL,LDL ,TGS are increased and thus these indicate hyperlipidemia.Echocardiograph : shows mild concentric left ventricular hypertrophy.
Slide6Assessment:
Chest pain:
This occurs due to reduced blood supply to the heart and thus this leads to chest pain.
Hyperlipidemia:
It is an elevation in one or more of the following: cholesterol, cholesterol esters, phospholipids or triglycerides. This results in predisposition in the coronary artery.
Slide7STANDARD THERAPY:
PROBLEM
GOALS
OF TREATMENT
DRUGS AND
MOA
DOSAGE
HyperlipidemiaTo lower LDL and Cholesterol.Reduce risk of recurrent events such as MI and angina, ischemic heart disease.HMG-COAREDUCTASE: They inhibit conversion of HMG-COA to mevalonate.They also reduce synthesis of LDL and enhance catebolism.
BILE ACID RESINS:
They bind to bile acids in the intestinal lumen and stimulate hepatic
syntesis
of bile acid from cholesterol.
FIBRIC ACID DERIVATIVES:
Reduce synthesis of VLDL
Atorvastatin
10mg
Rosuvastatin
5-10mg
Cholestyramine
8mg TID
Colestipol
10mgBID
Fenofibrate
54-67mg
Slide8