PPT-Cholesterol-Lowering Drugs

Victor Nadler Objectives By the end of this class students will be able to Explain the role of dietary lipids and endogenous lipoproteins including dietary cholesterol chylomicrons VLDLC LDLC and . High blood cholesterol is one of the major risk factors for heart disease A risk factor is a condition that increases your chance of getting a disease In fact the higher your blood cholesterol level the greater your risk for developing heart disease In fact the higher your blood cholesterol the greater your risk of developing heart disease or having a heart attack Heart disease is the 1 killer of men and women in the United States Each year more than a million Americans have a heart attack and 1. What is Cholesterol?. A waxy substance – technically a sterol (unsaturated steroid alcohol). 75% of your cholesterol is made in your liver, the rest is absorbed from food. Cholesterol travels in particles called lipoproteins: high-density lipoproteins (HDL) and low-Density Lipoproteins (LDL). Learning outcome. Most cholesterol is synthesised by the liver from saturated fats in the diet. Cholesterol is a component of cell membranes and a precursor for steroid synthesis. High-density lipoprotein (HDL) transports excess cholesterol from the body cells to the liver for elimination. This prevents accumulation of cholesterol in the blood. Low-density lipoprotein (LDL) transports cholesterol to body cells. Most cells have LDL receptors that take LDL into the cell where it releases cholesterol. Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas. A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis. . “Okay. ! We have successfully prepared the patient for the lowering of the electrode. We have the exact coordinates and angles that will help us know where to drill a hole and reach the VIM thalamus. It is incredibly important this is done correctly, or else a blood vessel could be hit that can cause a stroke. egg yolk. Lipids. Lipids. are. Biomolecules. that contain fatty acids or a steroid nucleus.. Soluble in organic solvents but not in water.. Named for the Greek word . lipos. , which means “fat.”. The Good, the Bad and the Ugly. What is Cholesterol?. Cholesterol is a waxy fat steroid. It is manufactured in the :. Liver. Intestines. Adrenal glands. Sex organs. Cholesterol is only synthesized in animals. Rachel . Randle. Clinical Scientist in-service HSST. Viapath Bedford Hospital. Dr W Wassif. Consultant . Chemical . Pathologist. Bedford Hospital. On behalf of National . Clinical Biochemistry Audit Group. Cholesterol. Is the most abundant . steroid. in the body.. Is a . waxy. substance found in all of the body cells. . Has . methyl. CH. 3. - groups, alkyl chain, and -OH attached to the steroid nucleus.. UNIT III:. Lipid Metabolism. HDL . comprise a heterogeneous family of lipoproteins with a complex metabolism that is not yet completely understood. . HDL particles are formed in blood by the addition of lipid to . Beth Kalicki. Heli. J. Roy, PhD, RD. Pennington Biomedical Research Center. Cholesterol Trends. Blood cholesterol levels correlate with weight. However, lean individuals can have high cholesterol levels.. Lowering Sodium without Losi ng Flavor Union Public Schools Tulsa, Oklahoma Lisa Griffin, RD, LD Callie Fowler- Farish Director of Child Nutrition District Executive Chef Union Public Schools-Tulsa, OK Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. 2013 ACC/AHA Guideline on the. Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults. IMPROVE-IT. 2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia.