PPT-Lab 5 –Blood, Lymphatics and the Immune Response

Gilbert Pitts PhD Joseph Schiller PhD James F Thompson PhD Objectives Examine Lymph node slide Lymphatic vessels on charts and models Blood slides Differentiate red blood cells platelets neutrophils lymphocytes monocytes eosinophils and basophils. Another Example of Cellular Communication. Key attributes of immune system. 4 attributes that characterize the immune system as a whole. specificity. antigen-antibody specificity. diversity. react to millions of antigens. Super Awesome Powers of Cell Signaling!. Reminder - Do the Questions!. Do the questions, or Mrs. Davis will be so super sad. Plus, this stuff is AWESOME.. Immunologists. 10-11 years of schooling/training. Immunology. - the study of host defense mechanisms. Immunity. -. ability of the host to protect itself against foreign organisms. Resistance to disease.. Antigen (Ag)- . is a foreign substance that can elicit specific immune response (IR) when is immunogenic. LYMPHOCYTES. Are the key cells of the immune system. Two types: B and T. Both produced in the bone marrow. B matures in the bone marrow. T matures in the thymus. Immunocompetency. B and T lymphocytes must recognize “self.”. Plants and animals have a variety of chemical defenses against infections that affect dynamic homeostasis.. Fig. 43-2. INNATE IMMUNITY. Recognition of traits. shared by broad ranges. of pathogens, using a. Pathogen. Complement fixation. Pyrogens. Chemotaxis. Immunocompetant. Autograft. Isograft. Allograft. Xenograft. Hapten. Allergy/. hypersensitiviy. Immediate/acute hypersensitivity. Anaphylactic shock. Chapter 4. Introduction. Molecules recognized as “non-self” are antigens. Several mechanisms to protect itself . First level of protection include physical and biochemical-skin, acid in stomach. Second level of protection phagocytic cells, enzymes, and proteins. In this compound light micrograph purple-stained neutrophil (upper left) and . eosinophil (. lower right) are white blood cells that float among red blood cells in this blood smear. . Neutrophils provide . To protect the body from infection or disease. Can be infectious or noninfectious. Infectious Disease. Disease caused by pathogens (bacteria, viruses, fungi, . protists. ). How pathogens are spread. Infected people. The Immune System. The immune system is a group of cells & soluble molecules, which interact & distinguish patterns in the body as “self” or “non-self,” in order to eliminate those that are “non-self.”. By: Brittaney Luu. The Innate Immune Response. Symptoms. The Physical Barrier. A . keratin plug . is present in non-lactating women to prevent the entry of bacteria created from the stratified squamous epithelium.. Immunological unresponsiveness to self is referred to as . tolerance. or . self-tolerance. Very important to human health. How is this achieved?. -cells with receptors for self-antigens are destroyed in the thymus or bone marrow (central tolerance). Hypersensitivities. Hypersensitivity. Any immune response against a foreign antigen exaggerated beyond the norm. Four types. Type I (immediate). Type II (cytotoxic). Type III (immune complex–mediated). Adaptive . Non-adaptive (. cell injury-----cell death). hypertrophy. Dysplasia. hyperplasia. neoplasia. Atrophy. Degeneration. Metaplasia. Necrosis, apoptosis. & gangrene. Reversible. Reversible* / Irreversible.