PPT-Mutations & Genetic Recombination

Mutation Permanent change in the genetic material of an organism All mutations in gametes are inheritable because they are copied during DNA replication Somatic cell mutations occur in body cells. Changes in . DNA. that affect genetic information. Gene Mutations. Point Mutations – changes . in one or a few. nucleotides. Substitution. THE FAT CAT ATE THE RAT. THE FAT HAT ATE THE RAT. Insertion. Elie Traer. September 13, 2012. Outline. Genetic tests and methodology. Cytogenetics. , i.e. large chromosomal abnormalities. FISH, smaller chromosomal changes. Genetic mutations. AML. Evolution of genetic tests in diagnosis and prognosis. Gil . McVean. There are no new questions in population genetics. …only new types of data. Genome sequences of entire populations. Data with linkage to deep phenotype information. Data from multiple species. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . HORT6033. Molecular . Plant . B. reeding. Instructor: Ainong . Shi. HORT6033 web site: . http://comp.uark.edu/~ashi/MB. . Fall 2014 HORT6033. Molecular Plant Breeding. Lecture 9 . (09/22/2014). Genetic map construction. ’. and the chromosome. Recombination between an F. ’. and a strain with a deletion (this doesn. ’. t give Lac ). Recombination between an F. ’. and a strain with a deletion (this . does. give Lac ). M. istakes made in the DNA sequencing. They can have a range of effects.. They can affect the genetic information that is passed to offspring.. Cells have evolved various methods to deal with them. . The sequence of bases in DNA are like the letters of a coded message or even the letters of a simple alphabet. . If we change the sequence of the letters do we change the nature of the message?. That . Unit 8: Protein Synthesis . 6A: Identify components of DNA, identify how information for specifying the traits of an organism is carried in the DNA, and examine scientific explanations for the origin of DNA.. Independent Assortment & Linkage. Genetic & Physical Maps. Lecture 1- Genetics. Madan K. Bhattacharyya, Ph.D.. Professor, Iowa State University. Adjunct Prof., Assam Agricultural University. mbhattac@iastate.edu. Wellcome. Trust Advanced Courses; Genomic Epidemiology in Africa. , . 21. st. – 26. th. June 2015. Africa . Centre for Health and Population Studies, University of KwaZulu-Natal, Durban, South Africa. Discovery. Genetic linkage was first discovered by the British. . geneticists William Bateson, Edith Rebecca Saunders and Reginald Punnett. . shortly after Mendel's laws were rediscovered. The understanding of genetic linkage was expanded by the work of Thomas Hunt Morgan. . Learning Goal . Identify the type of change in DNA for a point mutation, a deletion mutation, and an insertion mutation. . Genetic Mutation. A. . mutation. is a change in the nucleotide sequence of DNA.. R. ecombination. 2. . Site-Specific . R. ecombination. 3. DNA . Transposition. Homologous Recombination at the Molecular Level. DNA BREAKS ARE COMMON AND INITIATE RECOMBINATION. Recombination repair DNA breaks by retrieving sequence information from undamaged DNA.