PPT-Group 2 Innate Lymphoid Cells in Nasal Polyposis

Whitney W Stevens MD PhD Atsushi Kato PhD Ann Allergy Asthma Immunol February 20211262110117 Group 2 Innate Lymphoid Cells in Nasal Polyposis Key Messages Type 2 cytokines interleukin IL4 IL5 and IL13 are highly elevated and play a critical role in the pathogenesis of chronic rhinosinusitis with nasal polyps. Smad4 is a key part of TGF beta signaling pathway. Inhibits epithelial cell growth. SMAD4 is a tumor suppressor. . that was discovered in association with pancreatic cancer. De . Bosscher. . et al., . gene . expression. . Ronald S. . Veazey. , DVM, PhD. Division of Comparative Pathology. Tulane National Primate Research Center. Covington, Louisiana. Tulane University School of Medicine. New Orleans, Louisiana. 1. 33. Copyright © McGraw-Hill Global Education Holdings, LLC. Permission required for reproduction or display.. Immunity. Nonspecific . immune . response – . Ch. 33. Aka . nonspecific . resistance. E . Wolf decoy for geese (plenty in New England).. Why are these decoys efficient?. Geese do not have pictures to teach their young ones what animals to avoid…. … and so they must be born with images of predators engraved in their brain. Kuby Immunology. , . 7e: Chapter 2. Cells of the immune system. Immune responses result from coordinated activities of many cells, organs, and microenvironments in the body. Hematopoietic stem cells (HSCs) have the ability to differentiate into many types of blood cells. Polyposis. Syndromes in the Mediterranean Region. Thomas M Attard MD FAAP FACG. Associate Professor, Pediatrics, Gastroenterology, University of Malta, Malta. . Consultant Gastroenterologist Children’s Mercy Hospital, Kansas MO, USA.. Abbas. University of California San Francisco. FOCiS. Lecture outline. Components of innate immunity. Recognition of microbes and dead cells . Toll Like Receptors. NOD . Like Receptors/. Inflammasome. Dr. . M.A.Thomas. . FUNCTIONS . OF THE IMMUNE SYSTEM. :. Recognize. , destroy and clear a diversity of pathogens. .. Initiate . tissue and wound healing processes. .. Recognize . and clear damaged self components. Primary lymphoid tissue. : Bone marrow, Bursa of fabricius, Thymus.. Secondary lymphoid tissue. : Lymph node, Spleen.. Tertiary lymphoid tissue. : Mucosa-associated lymphoid tissue, Intra-epithelial lymphocytes.. Marco Novelli FAP, MAP, NAP and PPAP Marco Novelli Overview • History of polyposis • Familial adenomatous polyposis • MYH - associated polyposis • NTLH1 - associated polyposis • Other polypo Posted on Friday, March 12, 2004 DURHAM, N.C. -- Two seemingly disparate hereditary syndromes actually stem, in some patients, from a uke University Medical Center genejuvenile polyposis -- characteri An Introduction to MUTYH Associated Polyposis(MAP)ContentsWhat is MUTYH Associated Polyposis (MAP)? What causes MUTYH Associated Polyposis (MAP)? 3 How is MAP inherited? 4 enetic Testing 5 ow is MAP m Authored by Prof Michael C Herbst [D Litt et Phil (Health Studies); D N Ed; M Art et Scien; B A Cur; Dip Occupational Health] Approved by Ms Elize Joubert, C hief E xecutive O fficer [BA Social Wor There are lots of . micoorganisms. that we . encounter everyday . through breathing, touching, and eating. . Most are detected and . destroyed within minutes or hours . by defense mechanisms that do not rely on the clonal expansion of antigen-specific lymhphocytes. .