PPT-Innate Host Resistance

1 33 Copyright McGrawHill Global Education Holdings LLC Permission required for reproduction or display Immunity Nonspecific immune response Ch 33 Aka nonspecific resistance. non-AIDS Morbidity. Peter W. Hunt, MD. Associate Professor of Medicine. UCSF HIV/AIDS Division. A shift in focus…. T cell activation as a target for interventions in the pre-ART era. Monocyte activation and inflammation a target during treated HIV disease. Chapter 16: Innate (nonspecific) Immunity. Some terms:. Susceptibility. : Lack of immunity to a disease.. Immunity. : Ability to ward off disease.. . . immunity. : Defenses against any pathogen.. Innatism. Today we will be considering the following criticisms of Concept . Innatism. :. Alternative explanations for proposed innate ideas.. Locke’s arguments against . I. nnatism. Innatism’s. reliance on the non-natural.. Evolutionary View. Epithelial barriers to infection. Four main types of innate recognition . molecules:TLRs. , CLRs, NLRs, RLRs. NF-. . B, the master transcriptional regulator of inflammation . Inflammation and recruitment of phagocytes. Etholgy. Vs Psychology. Ethology: . the study of animal behavior in natural conditions. Ethologists work “in the field” observing natural behaviors, affecting their world as little as possible. Psychology: . A. The body has two main mechanisms of defenses. 1. Innate defense mechanisms – first line of defense. A) These defenses are non-specific and . inherited. Immunity Overview. B) Examples:. 1. ) Physical barriers. All organisms have innate behaviors that are inherited from parents that develop independently from the environment. Innate behavior is inherited from an individual’s parents and is not modified by the individual and is generally not affected by the organism’s environment, including an organism’s experiences.. Strengths. Weaknesses. p.129-131, . You have 3 minutes to read through the chart you made for homework. . Criticism 1: Is the Causal Principle true?. Without . using your notes, talk to the person next to you about how you would complete this piece of text: . Michael Lacewing. enquiries@alevelphilosophy.co.uk. © Michael Lacewing . Innate concepts. Some of our concepts are innate. ‘Innate’: some concepts are somehow part of the structure of the mind rather than being gained through experience.. In peer-to-peer networks such as gnutella , each host must search out other hosts. When a host finds another host, these hosts become neighbors. Often a host will continue to search for peers until a sufficient number of hosts have been found. Lets assume that a host will continue to search for hosts until it has N neighbors. What is it?. Innate Behavior. “Automatic” behavior. AKA instinct. Strong genetic component. Learned Behavior. What is it?. Learned Behavior. Behavior that is the result of experience or observation. Learning objectives. By the end of this session student will be able to. . Define innate immunity, acquired immunity. . To understand cells involved in . innate . and acquired . immunity. IMMUNITY. Abbas. University of California San Francisco. FOCiS. Lecture outline. Components of innate immunity. Recognition of microbes and dead cells . Toll Like Receptors. NOD . Like Receptors/. Inflammasome. There are lots of . micoorganisms. that we . encounter everyday . through breathing, touching, and eating. . Most are detected and . destroyed within minutes or hours . by defense mechanisms that do not rely on the clonal expansion of antigen-specific lymhphocytes. .