PPT-4b. Innate (nonspecific) Immunity

Chapter 16 Innate nonspecific Immunity Some terms Susceptibility Lack of immunity to a disease Immunity Ability to ward off disease immunity Defenses against any pathogen. Evolutionary View. Epithelial barriers to infection. Four main types of innate recognition . molecules:TLRs. , CLRs, NLRs, RLRs. NF-. . B, the master transcriptional regulator of inflammation . Inflammation and recruitment of phagocytes. Present before exposure to pathogens. Present at birth. Non-antigen specific. Consists of:. Skin… barrier for microbes and viruses. Compromised by abrasion or laceration. Sebacious. sweat is acidic (pH 3-5)… prevents colonization of bacteria. • Lecture 1Defining Innate ImmunityRecognition and effector mechanisms (I)• Lecture 2Recognition and effector mechanisms (II)Integration of innate and adaptive immune responses http://www.br Clarence Lam, . Sanket. Patel, . Tairan. Yang, Narthaanan Srimurugathasan. PHM142 Fall 2016. Instructor: Dr. Jeffrey Henderson. Outline. Introduction and components of innate immunity. Differentiation from blood cells and mechanisms of phagocytosis. A. The body has two main mechanisms of defenses. 1. Innate defense mechanisms – first line of defense. A) These defenses are non-specific and . inherited. Immunity Overview. B) Examples:. 1. ) Physical barriers. Chapter 16: Innate (nonspecific) Immunity. Some terms:. Susceptibility. : Lack of immunity to a disease.. Immunity. : Ability to ward off disease.. . . immunity. : Defenses against any pathogen.. Learning objectives. By the end of this session student will be able to. . Define innate immunity, acquired immunity. . To understand cells involved in . innate . and acquired . immunity. IMMUNITY. THE IMMUNE RESPONSE AND IMMUNITY. Immune response. Innate (non-specific). Adaptive or Acquired (specific). Defense . Mechanisms. Nonspecific. defense mechanisms. Specific. defense mechanisms. (immune. Abbas. University of California San Francisco. FOCiS. Lecture outline. Components of innate immunity. Recognition of microbes and dead cells . Toll Like Receptors. NOD . Like Receptors/. Inflammasome. Dr. . M.A.Thomas. . FUNCTIONS . OF THE IMMUNE SYSTEM. :. Recognize. , destroy and clear a diversity of pathogens. .. Initiate . tissue and wound healing processes. .. Recognize . and clear damaged self components. Dr. . Bipin. Patel. introduction. INTRODUCTION. The term “immunity” is referred to the . resistance of an individual . towards . injury. caused by . microbial stimuli . (microorganisms & their products) & . Defenses of the Host. 16. Mucus in the mucous membranes is produced by. endothelial cells.. goblet cells.. the lacrimal apparatus.. ciliated epithelial cells.. Mucus in the mucous membranes is produced by. catherine. . hartnett. The Immune System. Concept 43.1- In innate immunity, recognition and response rely on shared traits of pathogens. Introductory Video. http://www.cleanvideosearch.com/media/action/yt/watch?v=Nw27_jMWw10. There are lots of . micoorganisms. that we . encounter everyday . through breathing, touching, and eating. . Most are detected and . destroyed within minutes or hours . by defense mechanisms that do not rely on the clonal expansion of antigen-specific lymhphocytes. .