PPT-Congenital Macrocytic Anemia

Beng Fuh MD Assistant Professor of Pediatrics Pediatric Hematologyoncology East Carolina University No relevant financial relationships with the manufacturers of any commercial products andor providers of services discussed in this CME activity . DEFINITION & CLASSIFICATION. Maj. Gen (R) . Masood. Anwar. Professor of . Haematology. Functions of blood. Transport of nutrients. Transport of gases. Haemostasis. Defence. Composition of blood. Ellis J. Neufeld MD, PhD. Disclosure Information. Ellis J. Neufeld MD, PhD. Research Funding: . Agios. Pharmaceuticals. Advisory Board: . Agios. Pharmaceuticals. Hemolytic Anemia. Increased . destruction . Anemia:. Deficiency of hemoglobin in the blood.. Causes: . Too few RBCs.. Too little hemoglobin in cells. Decreased packed cell volume.. This may be due to. :. decreased production of RBCs.. increased destruction.. . ANEMIAS. Done by: Mohammad Saleh. Mosab Abu . Shqeer. Hamza . Alhamdan. Definition. A decrease in hemoglobin ( . Hb. ) , hematocrit ( . Hct. ) , or RBC count.. Measurement. Men. Women. Hemog. l. obin (g/dL). a sign . of an underlying . disorder. There are several kinds of anemia. . A. . physiologic . approach classifies anemia according to whether. the deficiency in erythrocytes is caused by a defect in . referance. range for the age and sex. The normal ranges vary with age . -neonate < 14g/dl. -1-12mths < 10mg/dl. -1-12y< 11 g/dl. Causes of anemia can be from. Reduced cell production. Increased destruction. a pathophysiological condition in which the body cannot meet its demands for oxygen. . M: . Hb. <13.5 . Hct. <41 . F. : . Hb. <12 . Hct. <36 . Erythrocyte Indices . Hgb. M: 14.0-18.0 . Michael R. Jeng, MD. Michael R. Jeng, MD. NO FINANCIAL DISCLOSURES. 1. Red blood cell biology. 2. Hemolytic anemia: definition, assessment. 3. Approach to diagnosis. 4. . Microangiopathic. hemolytic anemias. .. Epidemiology.. Classification.. Review the terminology used to discuss anemia.. Evaluation:. .. . • Address clues in the history and exam that can direct the evaluation. . • Describe one approach to using lab tests to make the diagnosis. . April 12, 2014. Virginia Harrod, MD, PhD. Pediatric Hematology Oncology. Overview . Definition of anemia. Review of CBC values. Review of Hemoglobin. Types of Anemia. Microcytic, macrocytic, normocytic. R.P.N. 13865. Definicion:. D. isminucion de la masa de eritrocitos circulantes; . Hb menor a 12g/dl o Hto menor a 36% en mujeres;. Hb menor a 14g/dl o Hto menor a 41% en hombres. .. Clasificacion:. P. 1, 2]. Table shows the genetic basis of most common membrane defects. Glucose-6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK), are the most common enzyme deciencies, showing an X-linked an April 2015 P Dr. Yoganathan. C Dissertation submitted to the Department of General Medicine P.S.G Institute of Medical Sciences & Research, Coimbatore CERTIFICATE BY THE GUIDE This is to certify that COLLEGE OF MEDICINE. DEPARTMENT OF PATHOLOGY AND FORENSIC. Medicine. Dr. . Ala’a. . A.Razak. . Abood. Iraqi Board of . Haematopathology. O. bjectives. :. Define macrocytic anemia and mention the major causes..