Doughter cells G2 phase Nuclear division Cytokinesis 1x DNA damage STOP activation of p53 Checkpoint arrest DNA damage checkpoint DNA repair expression of Wip1 inactivation of p53 ID: 1045570
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1. Normal cell cycle DNA replicationDoughter cellsG2 phaseNuclear divisionCytokinesis1x
2. DNA damageSTOP activation of p53Checkpoint arrestDNA damage checkpoint
3. DNA repair,expression of Wip1,inactivation of p53DNA damageSTART activation of p53Recovery from the checkpoint after DNA repair
4. DNA damageAbnormally high level of Wip1inactivation of p53deficient checkpointGenome instabilityAccumulation of mutationsCancerTransmission of Mutations to progenyRole of Wip1 oncogene in tumourigenesis100x