PPT-THE LIVER Bilirubin metabolism, types of jaundice

Dr Muntadher Abdulkareem Abdullah MBChBCABMFIBMSFIBMSGEampHEP At the end of this lecture you must be able to answer these questions Q1 22 year old male patient with history of recurrent self resolving jaundice since childhood presented with jaundice at the end of heavy duty day otherwise the patient is healthy with nonsignificant other finding. Conclusions . . * . Jaundice indicates that there is an elevated concentration of bilirubin in serum.. * In neonates it is important to determine the concentration of unconjugated bilirubin in order to decide what treatment is required.. Disorders. Saul J. Karpen, MD, PhD. Professor of Pediatrics. Raymond F. . Schinazi Distinguished Biomedical . Chair. Division Chief, . Gastroenterology, . Hepatology & . Nutrition. Emory University School of . It permits examination of liver cells. . Liver biopsy is especially useful when clinical findings and laboratory tests are not diagnostic.. Bleeding and bile peritonitis after liver biopsy are the major complications;. Measurement of Serum Bilirubin (Total, direct &indirect) . T.A. Bahiya Osrah. Bilirubin. Bilirubin. is the product of . heme. degradation (80% hemoglobin, 20% other . hemo. -protein as . cytochrome. Pediatric Continuity Clinic Curriculum. Onyekachukwu Osakwe. Objectives. Recognize the common findings in newborns with . hyperbilirubinemia. . . Describe bilirubin metabolism. Distinguish between direct and indirect . Professor of Biochemistry and Clinical Biochemistry. . Faculty of Veterinary Medicine, . Moshtohor. , . Benha. University, Egypt.. E.Mail:Samyaziza@yahoo.com. JAUNDICE. . . Jaundice . (also called . Objective. To estimate the amount of bilirubin in serum.. Bilirubin. It . is a by. -. product of the breakdown of hemoglobin. . (Yellow color). Bilirubin. Types of Bilirubin. . Direct bilirubin. : . Functions of the liver . 252 . Jaundice . 263 . Biochemical tests for liver disease . 255 . Bile and gallstones . 264 . Diseases of the liver . 257 . Investigation of suspected liver disease . 266 . This chapter looks at the chemical pathology of liver . Objectives. Understand etiology and pathophysiology of neonatal jaundice and kernicterus. Identify high risk conditions. Understand limits of clinical exam. Describe appropriate evaluation. Apply appropriate treatment to term and near term infants. Conversion of Amino Acids to Specialized Products . 1. . Overview . In addition to serving as building blocks for proteins, amino acids are precursors of many nitrogen-containing compounds that have important physiologic functions (Figure 21.1). . . . Shaimaa. . Munther. . Basic Anatomy. • liver unequally divided. into 2 lobes. • it has a dual blood supply. – Portal vein. – Hepatic artery. It has an excretory system for bile excretion. Junior resident. Dept. Internal . M. edicine. Jaundice. Yellowish discoloration of . body tissues resulting . from the deposition of bilirubin.. Tissue deposition occurs only in the presence of serum hyperbilirubinemia and is a sign of either liver disease ,haemolytic . Alzoghaibi. , . Ph.D. zzoghaibi@gmail.com. Phone call, . WhatsApp. : 0506338400. Bilirubin. Bilirubin: is the end product of . heme. degradation derived from breakdown senescent (aging) erythrocytes by mononuclear phagocytes system specially in the spleen, liver and bone marrow. . M.B.Ch.B,CABM,FIBMS,FIBMS(GE.&HEP.). Objectives:. At end of this lecture, the student should know :. 1.What is jaundice ?. 2. Types of jaundice?. 3. How you approach to each type of jaundice?. Jaundice.