TB in human Animal amp human Smear Lon and thin Short ampthick Culture by LJ media with addition of glycerol Rich and confluent improved by glycerol Poor and discrete not improved Biochemical ID: 1007282
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2. Human TBBovine TBDiseaseTB in humanAnimal & humanSmear Lon and thinShort &thickCulture by L-J media with addition of glycerolRich and confluent improved by glycerolPoor and discrete not improved Biochemical ReactionNitrate reductionNiacin production+ve+veAnimal inoculationG.PigsRabbit +Local lesion and no death+++generalised lesion lead to death
3. Atypical mycobacterimAtypical because:grow on ordinary media- produce pigment-longer and some time called filamentousApportunistic M: cause disease only when immunity decreasedTuberculoid Mprodce TB like disease (pulmonary + lymphadenitis) called mycobacteriosis which is not tuberculosis and in many instance they are pulomary infection and there is no person to person transmision
4. Difference bet. MBT &Atypical MBResist decolorization with 5% acid not 20% ( in GROUP IV decolorized by alcohol and can be stained by gram stain and grow within 2 days)Longer and filamentousGrow slower (except p IV)Give usually pigmented smooth growth (Except GP III)Non pathogenic to guiana pigsResist TB drugsNo person to person transmission but from environment
5. M. LepreMorphologyStained by modified ZN stain (acid fast 5%& alcohol fast)Appear as pink bacilli arranged in groups and present it is intracellular MO.Not cultured by ordinary mediaAnimal pathogenicity :injected to armadillo (foot pad)→ granuloma at site of injection
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