PPT-Virus binding and entry

Virology lecture 3 Dr Sadia Anjum Entry of avian leukosis virus a model simple retrovirus Classically all retroviruses were thought to be pHindependent More recently ALV has been proposed to require low pH but in addition to its receptorinduced conformational change. 00 httpwwwstocktonpresscoukbjp brPage 2br Binding gating anity and ecacy The interpretation of structureactivity relationships for agonists and of the e57472ects of mutating receptors David Colquhoun University College London Gower Street London WC1 Entry is typically achieved by means of a membrane fusion reac tion occurring either directly at the cell surface following particle binding or in lowpH endosomes after endocytosis of bound virions Enveloped viruses have evolved a diversity of strat The Art of Reconstruction. In order to survive, viruses must be able to do the following:. 1. Find a host cell it can replicate in. 2. Bind to that cell. 3. Enter the cell. 4. Release its genome in order to replicate. Chloe Jones, . Isabel Gonzaga, and . Nicole Anguiano. BIOL398: Bioinformatics Laboratory. Loyola Marymount University. 10/15/14. Outline. -. V3 plays a critical role in coreceptor binding in gp120 protein to CD4 T cells . Mutating the Hantavirus glycoprotein to determine amino acid residues required for virus entry. Introduction. . Saliva. Urine. Feces. INFECTED. INFECTED. Introduction. Hantavirus Pulmonary Syndrome (HPS). Dalya. Basil. Antiviral Chemotherapy . (Prevention and Treatment of Viral Infection). Viruses are a leading cause of disease and death worldwide. Although public health measures and vaccines are the most effective ways to control many viral infections, preventive measures have not succeeded for numerous viral diseases. For some of these diseases, antiviral drugs have been developed.. In order to survive, viruses must be able to do the following:. 1. Find a host cell it can replicate in. 2. Bind to that cell. 3. Enter the cell. 4. Release its genome in order to replicate. 5. Replicate its genome. Pawan. Sharma. Assistant Professor. Mangalayatan University, India. Japanese encephalitis virus (JEV) is a flavivirus, . family . Flaviviridea. Causes disease to human beings: . Japanese Encephalitis (JE) . Sara Ramos-. Lorente. , Isabel Pérez-. Jover. , Cristina . Romero-. López. * . and Alfredo . Berzal. -Herranz*. 1. . Instituto de Parasitología y Biomedicina “López-. Neyra. ”, IPBLN-CSIC. PTS Granada. . . pathogenesis . Viral . disease. . :proliferation . of a harmful . virus.  inside . the body and cause disease.. . Viral pathogenesis . interaction . Rama . Karadsheh. . 1. , and Megan . Meuser. . 1. , Simon . Cocklin. . 1*. . 1. Department of Biochemistry, Drexel University, 245 North 25. th. Street, Philadelphia, Pennsylvania, USA. *. Corresponding author: sc349@drexel.edu. https://. serendip.brynmawr.edu. /. oneworld. /virus. EBOLA VIRUS. Ebola Virus Discovery. 1976. Inject in mice. Electron microscopy. Transmission of EBOV. . (and search for reservoir species). Microbes and Infection, 2005,. . Bristow. . MD,. . PhD. . (CU. . AMC. . Cardiology. . and. . CVI,. . PI) . Natasha. . Altman,. . MD. . (CU. . AMC. . Cardiology. . and. . CVI,. . Clinical. . PI) . John. . Messenger,. Collins MH, McGowan E, Jadi R, Young E, Lopez CA, Baric RS, et al. Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection. Emerg Infect Dis. 2017;23(5):773-781. https://doi.org/10.3201/eid2305.161630.