Ekin Yurdakul Bogazici University Prof Kutlu Ulgen Bogazici University Prof Yaman Barlas Bogazici University WIP Presentation THE 41 st INTERNATIONAL SYSTEM DYNAMICS CONFERENCE Chicago USA and Virtually ID: 1043587
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1. Dynamic Modelling of Circadian Rhythm Disorder and its Connections to Autism in FetusEkin Yurdakul, Bogazici UniversityProf. Kutlu Ulgen, Bogazici UniversityProf. Yaman Barlas, Bogazici UniversityWIP PresentationTHE 41st INTERNATIONAL SYSTEM DYNAMICS CONFERENCEChicago, USA and Virtually@systemdynamics_#isdc2023
2. Circadian rhythm disruption causes an increase in the risk of neuropsychiatric disorders during pregnancy in the fetusAutismEndocrine, nervous, and immune systems Shift workThe mechanisms have not yet been fully resolved to identify potential early diagnosisProblem StatementTHE 40TH INTERNATIONAL SYSTEM DYNAMICS CONFERENCEVirtually everywhere!#isdc2022THE 41st INTERNATIONAL SYSTEM DYNAMICS CONFERENCEChicago, USA and Virtually@systemdynamics_#isdc2023
3. Approach or Dynamic HypothesisTHE 40TH INTERNATIONAL SYSTEM DYNAMICS CONFERENCEVirtually everywhere!#isdc2022THE 41st INTERNATIONAL SYSTEM DYNAMICS CONFERENCEChicago, USA and Virtually@systemdynamics_#isdc2023Two Systems: Mother and fetusThree Subsystems:Endocrine, nervous, and immuneMain stock variables:Circadian Stress, Cortisol, Melatonin, ACTH, Interleukin 6 (Inflammatory Cytokine), Oxidative StressTime unit: hourPregnancy second trimester: brain development
4. Progress, Insights, and QuestionsTHE 40TH INTERNATIONAL SYSTEM DYNAMICS CONFERENCEVirtually everywhere!#isdc2022THE 41st INTERNATIONAL SYSTEM DYNAMICS CONFERENCEChicago, USA and Virtually@systemdynamics_#isdc2023Thoughts, feedback, and questions welcomeCausal Loop Diagram: