PPT-STUDY ON SIGNAL TRANSDUCTION PATHWAY RESPONSIBLE

FOR THE INSULIN MIMETIC ACTIVITY OF NEOHESPERIDOSE Taro Kimura Eisuke Kato Jun Kawabata Laboratory of Food Biochemistry Division of Applied Bioscience Graduate School of Agriculture Hokkaido University. DR AMINA TARIQ. BIOCHEMISTRY. Survival of a multicellular organism depends on their ability to adapt to the constantly changing environment.. Intercellular communication mechanisms are necessary for this adaptation.. Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Organisms. can function normally only if:. All the cells of their different organs communicating effectively with their surroundings. . Once a cell picks up a hormonal or sensory signal, it must transmit this information from the surface to the interior parts of the cell—. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand (first messenger). Receptor (transducer). Primary Effector. Second . messenger. Second effector, etc.. Target proteins/DNA. Ligands. Signal transduction . General features of signal transduction. Type of cell signalling. Type of Signal . transducer/Receptors. signal transduction. T. he . signal. . represents the information, . that is detected by specific . Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. More than 4 years experience in developing and analyzing mathematical models of complex bio-chemical reaction networks 10 Journal papers, 1 book chapter, 6 peer-reviewed conference papers, and 7 Z. Huang, Y. Chu, B. Cunha, and J. Hahn, General Steps. 1. Receptor activation by extracellular/ intracellular signal. . 2. Binding of adapter proteins to receptor domains. 3. Recruitment of other proteins. 4. Phosphorylation, Ubiquitination, Acetylation etc.. Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system. Hedgehog Pathway Antagonist IPI-926 . in Patients with Advanced Chondrosarcoma. Andrew J. Wagner. 1. , Peter Hohenberger. 2. , Scott Okuno. 3. , . Mikael. . Eriksson. 4. , Shreyaskumar Patel. 5. , Stefano Ferrari.