PPT-Fluoroquinolones

Mark S Johnson PharmD BCPS Associate Professor and Director of Postgraduate Education Fluoroquinolones Very popular class of antibiotics due to spectrum of coverage gram positive gram negative . : ciprofloxacin (Ciprogemifloxacin (Factive), levofloxacin Levaquin), lomefloxacin (Maxaquinmoxifloxacin (Avelox), norfloxacin (Noroxinofloxacin (FloxinTetracyclines : demeclocycline (Declomycindoxy Quinolones. comprise of synthetic anti-bacterial agent, . naphthyridine. derivative introduced in the treatment of UTI.. Clinical usefulness of . quinolones. is due to good oral absorption, activity against gram negative urinary pathogens and comparatively higher concentration in urine than that of plasma or tissue conc. . % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . Antibiotic Stewardship Program -ECHO. Update on Fluoroquinolones . Fluoroquinolone generations chart. Increased risk, greater than with most other antibiotics, for causing . C. difficile . colitis . Acute Tendonitis. % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . folate. -derived cofactors . are essential for the synthesis of . purines. and . pyrimidines. (precursors of RNA and DNA) and other compounds necessary for cellular growth and replication. . In . the absence of . Dr.. Rashmi . Rekha. Kumari. Asstt. . . Prof.. cum Jr. Scientist. Deptt. . Of . Vety. . Pharmacology and Toxicology. B.V.C, . BASU,Patna. Slelection. of Antimicrobial agent is determined by following factors. Sulfonamides can be divided into three major groups: . (1) oral, absorbable; . (2) oral, . nonabsorbable. . (3) topical. . The oral, absorbable sulfonamides can be classified as short-, medium-, or long acting on the basis of their half-lives. Antimicrobial resistance . Did we lose the magic bullet?. U. Theuretzbacher – . C. enter . f. or . A. nti-. I. nfective . A. gents, Vienna, Austria. Conflict of interest. Nothing to disclose. Self-assessment questions. and Urinary Tract. Antiseptics. I. FLUOROQUINOLONES. Nalidixic. acid is the predecessor to all . fluoroquinolones. , a class of man-. . made antibiotics. . Over 10,000 . fluoroquinolone. analogs have been synthesized, . Additional . findings from 2014 study . Vladimirs. . Strazdins. , MD. Riga, Latvia. May 9, 2018. Background. – . resistant. E.coli. Antimicrobial . resistance. (AMR) . is. . growing. . rapidly. Manuel Alejandro Coba-Males . 1, . *, Javier Santamaría-Aguirre . 2, . * and Christian D. Alcívar-León . 1. 1 . Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170521, Ecuador; macoba@uce.edu.ec (M.A.C.-M); cdalcivar@uce.edu.ec (C.D.A.-L). …the . Antimicrobial agents . Fourth Lecture . 2022. Assist. Prof. Mohammed AboKsour. Sulfonamides . are synthetic antimicrobial agents . that . contain the . active antibacterial . sulfonamide. Drugs. Folate-derived cofactors are essential for the synthesis of purines and other compounds necessary for cellular growth and replication. Therefore, in the absence of . folate. , cells cannot grow or divide. To synthesize the critical .