PPT-FLUOROQUINOLONES

Quinolones comprise of synthetic antibacterial agent naphthyridine derivative introduced in the treatment of UTI Clinical usefulness of quinolones is due to good oral absorption activity against gram negative urinary pathogens and comparatively higher concentration in urine than that of plasma or tissue conc . : ciprofloxacin (Ciprogemifloxacin (Factive), levofloxacin Levaquin), lomefloxacin (Maxaquinmoxifloxacin (Avelox), norfloxacin (Noroxinofloxacin (FloxinTetracyclines : demeclocycline (Declomycindoxy % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . Antibiotic Stewardship Program -ECHO. Update on Fluoroquinolones . Fluoroquinolone generations chart. Increased risk, greater than with most other antibiotics, for causing . C. difficile . colitis . Acute Tendonitis. % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . folate. -derived cofactors . are essential for the synthesis of . purines. and . pyrimidines. (precursors of RNA and DNA) and other compounds necessary for cellular growth and replication. . In . the absence of . 4. th. class \biology department . The Antimicrobial agents . Sulpha. drug &. Quinolones. . Prepared by. . Dr.Sawsan. . Sajid. AL-. Jubori. Dr.Saad. L. Hammed . Sulfonamide.  (also called . Jennifer Doan, pharm. D. Pharmacy resident, unity health. September 30, 2016. 1. Learning Objectives. Recognize potential fluoroquinolone toxicities that may occur with systemic fluoroquinolone use. Dr.. Rashmi . Rekha. Kumari. Asstt. . . Prof.. cum Jr. Scientist. Deptt. . Of . Vety. . Pharmacology and Toxicology. B.V.C, . BASU,Patna. Slelection. of Antimicrobial agent is determined by following factors. Antiseptics. 31. A. . . FLUOROQUINOLONES. Nalidixic. acid is the predecessor to all . fluoroquinolones. , a class of man-. . made antibiotics. . Over 10,000 . fluoroquinolone. analogs have been synthesized, . Antimicrobial resistance . Did we lose the magic bullet?. U. Theuretzbacher – . C. enter . f. or . A. nti-. I. nfective . A. gents, Vienna, Austria. Conflict of interest. Nothing to disclose. Self-assessment questions. and Urinary Tract. Antiseptics. I. FLUOROQUINOLONES. Nalidixic. acid is the predecessor to all . fluoroquinolones. , a class of man-. . made antibiotics. . Over 10,000 . fluoroquinolone. analogs have been synthesized, . Additional . findings from 2014 study . Vladimirs. . Strazdins. , MD. Riga, Latvia. May 9, 2018. Background. – . resistant. E.coli. Antimicrobial . resistance. (AMR) . is. . growing. . rapidly. Manuel Alejandro Coba-Males . 1, . *, Javier Santamaría-Aguirre . 2, . * and Christian D. Alcívar-León . 1. 1 . Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170521, Ecuador; macoba@uce.edu.ec (M.A.C.-M); cdalcivar@uce.edu.ec (C.D.A.-L). Drugs. Folate-derived cofactors are essential for the synthesis of purines and other compounds necessary for cellular growth and replication. Therefore, in the absence of . folate. , cells cannot grow or divide. To synthesize the critical .