PPT-Gene Expression and Cell Differentiation

CSCOPE Unit 08 Lesson 01 There are hundreds of different types of cells in your body and each type has a unique function Were going to compare some different types of cells to see how much they have in common . What does the operon model attempt to explain?. the coordinated control of gene expression . in bacteria. bacterial resistance to antibiotics. how genes move between homologous regions of DNA. the mechanism of viral attachment to a host cell. . in wounds undergoing negative pressure wound therapy. Nate . Stearrett. (presentation format shamelessly stolen from Jeff . Elhai. ). Chronic Wounds. http://wjes.biomedcentral.com/articles/10.1186/1749-7922-2-10. Draw 5 boxes. Draw the process of mitosis in each phase, and describe what is happening to the DNA in each phase. Interphase . Early. Mitosis. Mid-. Mitosis. Late. Mitosis. Final. Product. Assessment. Dr. Cassandra Tierney. Cancer Statistics. http://www.cdc.gov. Quick Anatomy Lesson. How do you get Colon Cancer?. Nearly all colon cancers begin as noncancerous (benign) polyps, which slowly develop into cancer.. University of Notre Dame. Kristin Hager, Associate Teaching Professor, Biological Sciences. Joseph O’Tousa, Professor, Biological Sciences. WH Freeman. Marc Mazzoni, Senior Editor, Life Sciences. Elaine Palucki, Editor, Adjunct Assistant Professor Biology, Brooklyn College. How do we regulate the expression of our genes? . Involved in gene expression. DNA regulatory sequences. Regulatory genes. Small regulatory proteins (. RNAs. ). Regulatory sequences. Stretches of DNA that interact with regulatory proteins to control transcription.. How does a multicellular organism develop from a zygote?. How is the position of the parts of an organism determined?. How does differentiation of cell type occur in organisms?. How are genetics and development connected? Environment?. The earliest recognizable cell in the B cell lineage in the pro-B cell, in which the first stage of . Ig. H chain gene rearrangement takes place: A D. H. gene segment rearranges to a J. H. gene segment. Pro-B cells express CD19, it is expressed in all stages of B-cell development up to and including the mature B cell" but not plasma cells", pro B cells also express CD10. Hons. . 6. th. . sem. Paper: Developmental Biology. Unit 1 – Introduction (Continued) . Morphogens. :. The . cytoplasmic. proteins and transcription factors that form a gradient and determine polarity for Pattern Formation. Threshold value of . Kalsi . Heimdal. Background. What is epigenetics?. What is an epigenetic modification?. How could it help with cancer therapy?. 2. Acute Myeloid Leukemia (AML). 3. Most common type of acute leukemia.. Regulating . PROKARYOTIC. Gene Expression. Both prokaryotes and eukaryotes . alter their patterns of gene expression . in . response to changes in environmental conditions. .. During development, gene expression must be carefully regulated to ensure that the right genes are expressed only at the correct time and in the correct place.. . During . development, epigenetic information . is . acquired in a progressive . manner.. These . changes regulate the transcriptional . programme. during . lineage . commitment. . . Dynamic . regulation . Dr. Xiangyu Li. KTH-Royal In. stitute. of Technology. http://sysmedicine.com. 1. Where the transcripts come from?. 2. Pre-mRNA. Intron. Patterns . of alternative . splicing. 3. HPA 37 different human tissues. Pearley Chinta and Juliet V. Spencer . Abstract. Methods. Results. Conclusions. HCMV is a widespread pathogen in the general population and can cause severe disease in immune-compromised hosts. HCMV manipulates immune responses in several ways, one of which includes encoding genes with homology to host chemokine receptors. HCMV US27 encodes a chemokine-like receptor that stimulates host gene expression. While, no chemokine ligand has been identified for US27, it is constitutively active. US27 stimulates the gene expression of antioxidant response element (ARE) regulated genes by activation of the transcription factor nuclear respiratory factor 1 (NRF-1). The goal of this project is to identify specific host and viral genes that are regulated by US27. Increased expression of antioxidant genes is likely to benefit virus infection and enable more progeny virus to be produced. Thus, a better understanding of the US27 function has the potential to lead to the development of novel antiviral therapies necessary to treat HCMV infection. .