PPT-Rhinovirus Induces Th2 cytokines and chemokines in the Airw

David Jackson Clinical Research Fellow Department of Respiratory Medicine National Heart and Lung Institute Imperial College London Introduction Asthma is a chronic condition characterised by reversible airflow obstruction airway hyperresponsiveness and airway inflammation. Naturally high . stimulatory. . threshold. Regulation. . of. . immune. response. +/-. Stimulation. Anergy. , . apoptosis. Termination. . of. . im.resp. .. HOW. Th0. Th1,2,3,17. Treg. Apropriate. 22. Physiological mechanisms of regulation of the immune system. Cytokines (classification according to the function).. 23. Defence against extracellular pathogens .. 24. Defence against intracellular .. Immunology Ontologies and Their Applications in Processing Clinical Data. June 11-13, Buffalo, NY. Confessions. I am an ontological newbie. Idea for a new ontology of immune networks. Immunologists I’ve talked to like the idea. presented by. Dr . Hadeel. F. Gad. Leishmania . and Mycobacterium TB share many similarities in their pathogenesis and both pathogens are macrophage parasites. . Furthermore, . co-infection by the two pathogens is not uncommon in clinical practice in East Africa and in other parts of the world (Sati 1942; el-Safi et al. 1995; Khalil et al. 1998, . Response. A review. The 3 Lines of Defense. FIRST line: Barrier protection. non-specific (treats . each pathogen the . same). acts to prevent the pathogen from getting into the body. skin, mucous membranes, tears, sweat. Brown Bag. February 16, 2010. Synopsis of Topics. Overview of CD4 . T cell subsets. Th17 cells and . Tregs. . Mechanisms of commitment to individual lineages (Th1, Th2, Th17). Relationships between . Givi. , . Joerg. Weekly MicroMegas Meeting 12/3/2013. 1. MicroMegas Weekly Meeting 2013/03/12. Overview. TH2 chamber Vs . Txx. chambers. TH2 studies with X-ray. Cosmic stand for 10x10 cm chambers. TH2-Txx comparison with cosmic. presented by. Dr . Hadeel. F. Gad. Leishmania . and Mycobacterium TB share many similarities in their pathogenesis and both pathogens are macrophage parasites. . Furthermore, . co-infection by the two pathogens is not uncommon in clinical practice in East Africa and in other parts of the world (Sati 1942; el-Safi et al. 1995; Khalil et al. 1998, . Class name – VILS. Course name - LS-IMMUNOLOGY. (Rohit). Alternate Tick over pathway. We have discussed Fluid phase C3 convertase . Diagram depicts how fluid phase C3 convertase forms.. Membrane bound C3 convertase. Class name – VILS. Course name - ZOO-Biotech. (Rohit). How T-cells are activated. Two signals are required for T-cell activation namely Signal 1 and Signal 2. . Signal 1 . is provided by antigen-specific TCR . into Tissues. Chapter 3. CHEMOKINES AND CHEMOKINE RECEPTORS. Biologic Actions of Chemokines. Chemokines are essential for the . recruitment. of circulating leukocytes from blood vessels into extravascular. Objectives. General Properties of Cytokines and Chemokines. Six Families of Cytokines . Cytokine Antagonists . Cytokine-Related Diseases . Cytokine-Based Therapies. Dr. Refif S. Al-. Shawk. . Lec. Cytokines despite being nonspecific immunity it regulate the intensity and duration of the inflammatory/immune response.. Most cytokines are single polypeptide chains, may be aggregate as a homotrimer e.g. IL-12, IL-23. ®. Cytokines are rapidly secreted upon expression which results in. low / not detectable intracellular concentrations.. The use of secretion inhibitors allows for intracellular accumulation of cytokines:.