PPT-Polygenic Risk Scores Mayo Clinic & Illinois Alliance, Computational Genomics Course

Dan Schaid Curtis L Carlson Professor of Genomics Research Mayo Clinic Email schaidmayoedu Polygenic Risk Score PRS PRS Many Gene Score Weighted sum of genotypes across genetic markers SNPs . In More Good Reasons to Look at the Data we looked at data distributions to assess center shape and spread and described how the validity of many statistical procedures relies on an assumption of approximate normality But what do we do if our data IGSS 2015 Tutorial. Ben . Domingue. Gameplan. Overview. What are polygenic scores?. How are they used?. How are they created?. You create them.. Top hits. Homebrewed Genome-wide. PRSice. . Caveats, etc.. NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). Professor of Medicine Mayo Medical School Mayo Clinic Medical Director Mayo Clinic Care Network Dr Hayes is the Medical Director of the Mayo Clinic Care Clinic initiative that was build durable nati determine if patients meet the criteria and will schedule a drive-through test Tests will not be offered to people who have not been pre-screened over the phone The virus spreads rapidly and this proc is NOTpart of any preferred networksfor our insureds However itmay appear within the UnitedHealthcare network provider searchesPenalties will apply for charges incurred for services from out-of-networ For personal use Mass reproduce only with permission from Mayo Clinic ProceedingFor personal use Mass reproduce only with permission from Mayo Clinic ProceedingsN M PAIGE MD MSHS AND T NAGAMI MDRenal with thanks to Lucia . Colodro. Conde & Baptiste . Couvy. Duchesne. What are Polygenic risk scores (PRS)?. PRS are a . quantitative measure of the cumulative genetic risk . or vulnerability that an individual possesses for a trait.. London School of Hygiene and Tropical Medicine. October 2015. Classes of genetic disease. Monogenic. Clear phenotype. Mendelian. Oligogenic. Variable phenotype. Genetic heterogeneity. Polygenic. ‘continuous’ phenotype. Ida Surakka. PostDoctoral. Fellow. Department of Internal Medicine . Division of Cardiovascular Medicine. University of Michigan. Outline. Background for complex diseases. Genome-wide association analyses. For personal use. Mass reproduce only with permission from Mayo Clinic Proceedin g For personal use. Mass reproduce only with permission from Mayo Clinic Proceedin g s. From the Division of Hematology Dr. Gordon Wayne Dewald, 66, pionresearcher, teacher, and devoted husband, father, grandfather, and brother, died the evening of Friday, February 26, 2010 after a long courageous battle with acinar Using state-of-the-art MRI images, this book illustrates radiological findings in the abdomen and pelvis in a case presentation format. Cases presented in this book include common and uncommon diseases of nearly every organ system of the abdomen and pelvis. Each case succinctly discusses therelevant imaging findings, differential diagnosis, and potential imaging and diagnostic pitfalls. Many cases also include discussion of MRI technique, with illustration of some common artifacts. For radiology residents and fellows, this book will be a valuable study tool and reference fourth-yearresidents should find this book especially helpful when studying for oral boards. Practicing radiologists should find this a useful quick review of state-of-the-art body MRI. Legacy December 2014 Pioneers in Cardiac Surgery : The Mayo Gibbon Heart - Lung B ypass Machine In the March 13, 1955 , issue of The Proceedings of the Staff Meetings of the Mayo Clinic, Dr John