PPT-Polygenic risk scores Sarah Medland

with thanks to Lucia Colodro Conde amp Baptiste Couvy Duchesne What are Polygenic risk scores PRS PRS are a quantitative measure of the cumulative genetic risk or vulnerability that an individual possesses for a trait. th. Edition . Alexis Saperstein and Mary . S. tewart Anderson. EDSP 5311: Diagnostic and Prescriptive Teaching of Exceptional Children. Dr. Reed. Houston Baptist University. Outline. History. Description of the Test. IGSS 2015 Tutorial. Ben . Domingue. Gameplan. Overview. What are polygenic scores?. How are they used?. How are they created?. You create them.. Top hits. Homebrewed Genome-wide. PRSice. . Caveats, etc.. . & Nathan Gillespie. Types of Heterogeneity. Terminology depends on research question. Moderation, confounding, . GxE. Systematic differences. Measured or Manifest moderator/confounder. Discrete traits. Boulder 2015. What is imputation? . (. Marchini. & . Howie. 2010). . 3 main reasons for imputation. Meta-analysis. Fine Mapping. Combining data from different . chips. Other less common uses. sporadic missing data imputation . How Frequent Is Bleeding With NOACs?. Bleeding Risk: HAS-BLED. Bleeding Scores in AF. Biomarkers in AF. Reasons for and Implications of Elevated GDF-15 Level. GDF-15 in ARISTOTLE. GDF-15. Strongest Bleeding Marker. SGDP Summer School . July . 2010. Twin Model. Hypothesised. Sources of. Variation. Predicted Var/Cov. from Model. Structural Equation Modelling . (SEM). Path Tracing. Rules. Matrix . Algebra. Model. CSA: Analyzing the Relationship of Scores to Crash Risk Rebecca M. Brewster President and COO American Transportation Research Institute 2012 Top Industry Issues CSA Hours-of-Service Economy Driver Shortage human embryos for polygenic . traits?. Shai Carmi. Public Health. The Hebrew University of Jerusalem. HUJI. December 2019. scarmilab.org. @. ShaiCarmi. Genetic screening of embryos. Why?. Mendelian disease mutations. London School of Hygiene and Tropical Medicine. October 2015. Classes of genetic disease. Monogenic. Clear phenotype. Mendelian. Oligogenic. Variable phenotype. Genetic heterogeneity. Polygenic. ‘continuous’ phenotype. Ida Surakka. PostDoctoral. Fellow. Department of Internal Medicine . Division of Cardiovascular Medicine. University of Michigan. Outline. Background for complex diseases. Genome-wide association analyses. Colodro. Conde. sarah. /2020/. thursday. What are Polygenic risk scores (PRS)?. PRS are a . quantitative measure of the cumulative genetic risk . or vulnerability that an individual possesses for a trait.. A Look Across Maryland Hospitals. . . Diane . Alejo. ,. . Jennifer Bobbitt, . Filiz. . Costantini. , Diane Sender, Mary Brogan, Karen . Getson. , Angela Toro, Heather Romine,. Gail Hanna, Martha . st. September 2018. The Importance Of Genetics On Longevity . Risk. A . Study Based On Half A Million Lives In The UK Biobank Cohort. Peter Banthorpe. SVP, Global Head of Research and Data Analytics. . Dan Schaid. Curtis L. Carlson Professor of Genomics Research. Mayo Clinic. Email: schaid@mayo.edu. Polygenic Risk Score (PRS). PRS = Many Gene Score. Weighted. sum of genotypes across . genetic markers (SNPs) .