PPT-Heritability of disease A/Prof Loic Yengo

Genetics amp Genomics Winter School Group Leader Statistical Genomics Group Institute for Molecular Bioscience The University of Queensland Aim of this lecture In this lecture we will show why these statements are consistent . RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener Lipika. Ray. 4th . June 2010. Heritability:. Phenotype (P) = genotype (G) + environmental factors (E). (observed) (unobserved) (unobserved). Variances:. Heritability is defined as ratio of variances, by expressing the proportion of the phenotypic variance that can be attributed to variance of genotypic values:. GraphG prof 1 prof 2 prof 3 prof 4 phd 5 stud 6 stud 7 adv adv adv adv adv sup sup GraphI 1 prof 2,3 prof 4 prof 5 phd 6,7 stud adv adv adv sup 1Fortheformaldevelopmentinthispaper,itwillbeconve-nientt GraphG prof 1 prof 2 prof 3 prof 4 phd 5 stud 6 stud 7 adv adv adv adv adv sup sup GraphI 1 prof 2,3 prof 4 prof 5 phd 6,7 stud adv adv adv sup 1Fortheformaldevelopmentinthispaper,itwillbeconve-nientt RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener Chapters 6, 7, and 8. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. New Statistical Approaches. Or . Zuk. . Broad Institute of MIT and Harvard. orzuk@broadinsitute.org. www.broadinstitute.org/~orzuk. Genome . Wide Association Studies (GWAS). 2. l. ength: ~3x10. 9. ACCGAGAGGGTT. Walking . Man.  . By . Jonathan . Barofsky. .  . Leopoldstrasse. Munich Germany. Prof. Tariq Waseem. Case 1. A 55 yrs old university professor has noticed chest tightness and heaviness while walking a distance of 300 meters from car parking to his department. The feeling is relieved if he stops midway for a while and does not occur at all when he walks in company of his colleagues or students. He felt similar chest congestion going uphill in Murree during last summer vacations. A friend suggested a pill to be kept in mouth while walking and he felt relieved.. common . disease. AKA . –. everything is much harder in a binary trait. Naomi Wray. 1. Missing heritability . psychiatric disorders. N cases. N loci. h. 2. SNP-h. 2. Schizophrenia. 67K. 245. 80. 26. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. Genes and Inheritance. 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Course Outline. 1. Genes and Inheritance (GG). 2. Molecular Biology of the Genome (JL). 3. . Population and Evolutionary Genetics (JL). Naomi Wray. 2016 Module 18: . Statistical & Quantitative Genetics of Disease. 1. Aims of Lecture 1. If a disease affects 1% of the population and has heritability 80%. We will show why . these statements are . Naomi Wray. 2016 Module 18: . Statistical & Quantitative Genetics of Disease. 1. Misunderstandings in MZ twins. “Estimates of heritability of liability to a number of diseases turned out to be quite high. This was a surprise to those not versed in quantitative genetics who tended to think that low concordances rates in MZ twins implied low heritability.” Fraser (1976) . Associate . Professor. Dept. of Genetics and Animal Breeding. PSTU, . Barishal. campus. Overview. Definition. Scale of Heritability. Example. Uses of Heritability. Limitations of Heritability. Methods of Estimation of Heritability.