PPT-Heritability of disease A/Prof Loic Yengo

Genetics amp Genomics Winter School Group Leader Statistical Genomics Group Institute for Molecular Bioscience The University of Queensland Aim of this lecture In this lecture we will show why these statements are consistent . 1. ) A bit of basics. 2) Heritability (Ch 10). 3) Assortative mating (Ch 10). 4) Homework. 5) Questions, thoughts?. A bit of basics. Mean:. μ. x. = . Σ. x. i. / N. = (1+2+2+3+3+4) / 6 = 15/6 = 2.5. Lipika. Ray. 4th . June 2010. Heritability:. Phenotype (P) = genotype (G) + environmental factors (E). (observed) (unobserved) (unobserved). Variances:. Heritability is defined as ratio of variances, by expressing the proportion of the phenotypic variance that can be attributed to variance of genotypic values:. Danijela Takač. , prof. mentor. Učitelj fizike, tehničke kulture, informatike i astronomije. OŠ Pantovčak, Zagreb. Sandra Ivković. , prof. mentor. Učitelj  fizike, tehničke kulture, informatike i astronomije. GraphG prof 1 prof 2 prof 3 prof 4 phd 5 stud 6 stud 7 adv adv adv adv adv sup sup GraphI 1 prof 2,3 prof 4 prof 5 phd 6,7 stud adv adv adv sup 1Fortheformaldevelopmentinthispaper,itwillbeconve-nientt RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener Chapters 6, 7, and 8. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. New Statistical Approaches. Or . Zuk. . Broad Institute of MIT and Harvard. orzuk@broadinsitute.org. www.broadinstitute.org/~orzuk. Genome . Wide Association Studies (GWAS). 2. l. ength: ~3x10. 9. ACCGAGAGGGTT. Discussion – Pair and Share. What is a personality characteristic, talent, or skill that runs in your family?. Who in your family has it?. Make a little family tree chart depicting it. What is the likelihood that the trait is . Walking . Man.  . By . Jonathan . Barofsky. .  . Leopoldstrasse. Munich Germany. Prof. Tariq Waseem. Case 1. A 55 yrs old university professor has noticed chest tightness and heaviness while walking a distance of 300 meters from car parking to his department. The feeling is relieved if he stops midway for a while and does not occur at all when he walks in company of his colleagues or students. He felt similar chest congestion going uphill in Murree during last summer vacations. A friend suggested a pill to be kept in mouth while walking and he felt relieved.. common . disease. AKA . –. everything is much harder in a binary trait. Naomi Wray. 1. Missing heritability . psychiatric disorders. N cases. N loci. h. 2. SNP-h. 2. Schizophrenia. 67K. 245. 80. 26. heritability. (“GWAS and heritability”). peter.visscher@uq.edu.au. 1. The original definition of ‘missing heritability’. NB both are estimates that can be biased (up or down).  . 2. My 2009 presentation. Dr. Hannah Gordon, Prof Timothy Orchard, . Dr. Alan Steel, . Dr. Marcus . Harbord. ECCO 2015 Barcelona. Declarations:. The authors have no competing interests. Funded by an unrestricted grant from the Jesse and Thomas Tam Family Foundation. Associate . Professor. Dept. of Genetics and Animal Breeding. PSTU, . Barishal. campus. Overview. Definition. Scale of Heritability. Example. Uses of Heritability. Limitations of Heritability. Methods of Estimation of Heritability. Dr. Sonalika’s Eye Clinic provide the best Corneal disease treatment in Pune, Hadapsar, Amanora, Magarpatta, Mundhwa, Kharadi Rd, Viman Nagar, Wagholi, and Wadgaon Sheri