PPT-Missing Heritability

Lipika Ray 4th June 2010 Heritability Phenotype P genotype G environmental factors E observed unobserved unobserved Variances Heritability is defined as ratio of variances by expressing the proportion of the phenotypic variance that can be attributed to variance of genotypic values. RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener 1. ) A bit of basics. 2) Heritability (Ch 10). 3) Assortative mating (Ch 10). 4) Homework. 5) Questions, thoughts?. A bit of basics. Mean:. μ. x. = . Σ. x. i. / N. = (1+2+2+3+3+4) / 6 = 15/6 = 2.5. RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener Chapters 6, 7, and 8. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. Personality. Nature . v. . Nurture. Nature!. “They are born that way!”. Responsible for ~50% of personality. Nurture!. “It’s their experiences & how they were raised!”. Responsible for ~50% of personality. 3. rd. -Cycle . Pollen Mix Tests. Andrew Sims. Introduction. Pollen Mix (PMX) trials. 4 Coastal Series, 3 Piedmont Series. 51 total sites. Objectives. Estimate Breeding Values . Include large number of genetic entries. New Statistical Approaches. Or . Zuk. . Broad Institute of MIT and Harvard. orzuk@broadinsitute.org. www.broadinstitute.org/~orzuk. Genome . Wide Association Studies (GWAS). 2. l. ength: ~3x10. 9. ACCGAGAGGGTT. common . disease. AKA . –. everything is much harder in a binary trait. Naomi Wray. 1. Missing heritability . psychiatric disorders. N cases. N loci. h. 2. SNP-h. 2. Schizophrenia. 67K. 245. 80. 26. Lecture Notes. Key Question. Are physiological responses a . correlate . of the trait in question, or are they a . cause?. Example: Are shy people shy . because. they have certain physiological responses such as an increased heart rate, or are they shy because of some biological system that makes them that way?. Genes and Inheritance. 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Course Outline. 1. Genes and Inheritance (GG). 2. Molecular Biology of the Genome (JL). 3. . Population and Evolutionary Genetics (JL). heritability. (“GWAS and heritability”). peter.visscher@uq.edu.au. 1. The original definition of ‘missing heritability’. NB both are estimates that can be biased (up or down).  . 2. My 2009 presentation. Naomi Wray. 2016 Module 18: . Statistical & Quantitative Genetics of Disease. 1. Misunderstandings in MZ twins. “Estimates of heritability of liability to a number of diseases turned out to be quite high. This was a surprise to those not versed in quantitative genetics who tended to think that low concordances rates in MZ twins implied low heritability.” Fraser (1976) . Associate . Professor. Dept. of Genetics and Animal Breeding. PSTU, . Barishal. campus. Overview. Definition. Scale of Heritability. Example. Uses of Heritability. Limitations of Heritability. Methods of Estimation of Heritability. Associate Professor. Dept. of Genetics and Animal Breeding. PSTU, Barishal Campus. Repeatability. . Important repeated traits are. :. Milk production, egg production, number of offspring of goat in different litters..