PPT-Adrenergic Neurotransmission

Dr Nirbhay Kumar Asstt Professor amp Head Deptt of Veterinary Pharmacology amp Toxicology Bihar Veterinary College Bihar Animal Sciences University Patna The impulse transmission that is mediated by norepinephrine postganglionic sympathetic nerve terminals and CNS dopamine CNS and epinephrine adrenal medulla is in general called as adrenergic transmission All these transmitters are also called as . Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. β-adrenergic antagonists are commonly used to treat hypertension, angina, tremor, migraine, and panic attacks.. ACTION. β-adrenergic antagonists competitively antagonize the effects . of . catecholamines. Ms. . Carmelitano. Introduction. Neurons are the building blocks of behavior. The 10 to 100 billion neurons make about 13 trillion connections with each other over the synapses. Essential Question: How do messages cross the synapses?. ADRENERGIC RECEPTORS. . . α. 1. . α. 2. -Postsynaptic . Presyn. . (periphery). - Sm. M of peripheral B.V. - ↓ NT release . Def: The ANS consists of all visceral motor neurons innervating smooth muscle, cardiac muscle and glands.. Divide Autonomic Pharmacology into Four Categories:. 1. Drugs that increase the sympathetic nervous system response . DR. ISHOLA I.O.. DEPT OF PHARMACOLOGY, THERAPEUTICS AND TOXICOLOGY. CMUL. ADRENERGIC TRANSMISSION. Adrenergic transmission is restricted to the sympathetic nervous system. Norepinephrine. is the transmitter at post-ganglionic sympathetic nerves – except sweat glands . Adrenergic receptors Dr. S. Parthasarathy MD., DA., DNB, MD ( Acu ), Dip. Diab.DCA, Dip. Software statistics- Ph d Mahatma Gandhi Medical college and research institute , puducherry Adrenalin, Noradrenalin. Sympathomimetics (direct & indirect). Sympatholytics. Adrenergic Receptors. Removal of Norepinephrine. Diffuse out of the synaptic cleft. Metabolized by COMT. Reuptake into the neuron. Calcium Channel Blocker. WASU TACHAWATTANAKUL, M.D.. Objective. Pharmacologic properties of beta-adrenergic antagonist & calcium channel blocker. Clinical manifestation. Management & Antidote. Sympatholytics. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. These . sami. Cardiac Output (CO). CO =HR X stroke volume (SV). SV: is the amount of blood ejected from the ventricles with each beat – average is . approx. 70mls. SV is affected by . preload. , . contractility. . Dr. . Zahraa. M. . Ayad. Al-. mustaqbal. . University College. Department of . Nursing . 2. nd. Class. . Pharmacology /2. nd. semester. Adrenergic drugs (Sympathomimetic). Adrenergic drugs stimulate adrenergic receptors, thereby activating the sympathetic nervous system and inducing symptoms characteristic of the fight-or-flight response (sympathetic stimulation).. . Symaptholytics. Sensitivity of receptors. Two Families:. Alpha and Beta. Based on affinity to adrenergic agonists. Alpha affinity:. epinephrine. ≥norepinephrine. >> . isoproteranol. Beta affinity:. , Marina . Brasó. . i Abel . Eraso. MEMBRANE. PROTEINS. Index. . Introduction. What. . is. . cell. . membrane. ?. Integral . Proteins. Crystallization. . Transmembrane. . Proteins. β - . Barrels.