PPT-MUTATIONS

Changes in DNA that affect genetic information Gene Mutations Point Mutations changes in one or a few nucleotides Substitution THE FAT CAT ATE THE RAT THE FAT HAT ATE THE RAT Insertion. Mutations. Hollywood’s images of . mutation. Mutations. Actual Mutations . in fruit flies. What is a mutation?. A mutation is any change in a cell’s DNA. A mutation can occur in an individual gene. What Are Mutations?. Mutation: . Changes . in the nucleotide sequence of . DNA. Mutagen: . A physical or chemical agent that changes DNA. Mutation May . occur . in:. somatic cells (body cells): . will not be . Bases:. A, T, C, G. Codons:. Genes:. Chromosome:. DNA. Words. Chapters. Book. Not passed on to offspring. Can be passed on to offspring. M. ito. sis. M. eio. sis. Mutations. in Cell Division. A single gene. or. How a perfectly good system can go wrong go wrong go wrong. There are 2 types of mutations. 1)Chromosomal rearrangements. . There are too many or too few chromosomes. (nondisjunction and polyploidy). By Karl . Menzel. Is rearrangements or Point Mutations Faster. Synteny. Blocks and Chromosomes. Mouse Human. Chimp Human. Data Reading and Sliding Window. Human vs Chimp. Human vs Mouse. Mutation. Permanent change in the genetic material of an organism. All mutations in gametes are inheritable because they are copied during DNA replication. Somatic cell mutations occur in body cells. P Ferguson, L . Quek. , M . Metzner. , I Ahmed, C Garnett, S Jeffries, K . Piechocki. , R Danby, M . Raghavan. , A . Peniket. , M Griffiths, A Bacon, J Ward, K Wheatley, P Vyas, C Craddock. Introduction. and Causes. What kinds of mutations can occur?. Mutations:. Mutations: are changes in the genetic material.. Mutations can produce changes in a single nucleotide to a whole chromosome. . Gene Mutations:. >2500 cancer genomes: Overall . functional . impact. Slides freely . downloadable . from . Lectures.GersteinLab.org. . & “tweetable” . (via . @. markgerstein. ). . See last slide . for more info.. Nobody’s perfect all the time . About 1/10 billion base pairs end up with a error or mutation . Mutation: Mistake in DNA replication or an environmental effect that . results. in a change to the nitrogenous bases in DNA or RNA. . Point mutations. single base change . silent mutation. no amino acid change. redundancy in code. missense. change amino acid. Changes the final protien. nonsense. change to stop codon. Stopping prematurely . Given a mutation, identify its type. Predict how a mutation will affect a protein.. Mutations. Changes in genetic material (DNA). 2 main types of mutations. Point mutation- change in one or a few nucleotides (letters). Understand how they occur. Analyze the different types of mutations. Understand how mutations affect amino acid sequences and proteins. Objective. Central Dogma. DNA is transcribed into RNA, RNA is translated into proteins. There are two basic types of mutations:. Gene mutations - mutations that produce changes in a single gene. Chromosomal mutations - mutations that produce changes in whole chromosomes. Gene mutations .