PPT-Purine and Pyrimidine anabolism

OBJECTIVES Nomenclature of nucleic acids a nucleosides b nucleotides Structure and function of purines and pyrimidines Origin of atoms in the purine ring and in the pyrimidine ring. C483 Spring 2013. 1. A . ribose sugar is added to ________ rings after their synthesis and to ________ rings during their synthesis.. A) purine; pyrimidine. B) pyrimidine; purine. C) purine; purine. D) pyrimidine; pyrimidine. 1. Dr. Nikhat Siddiqi. 2. Dr. Nikhat Siddiqi. Biosynthesis of . histidine. in bacteria and plants. 3. Dr. Nikhat Siddiqi. Histidine. The pathway to . histidine. in all plants and bacteria . differs . BASIC STRUCTURE OF PURINES. DEGRADATION OF PURINES. ADENOSINE DEAMINASE DEFICIENCY. Leads to immunodeficiency disease in which T and B lymphocytes don’t develop.. Lack of ADA leads to increase in concentration of dATP- inhibitor of ribonucleotide reductase.. OBJECTIVES:. Nomenclature of nucleic acids: . a. nucleosides*. . b. nucleotides. Structure . and function of . purines and pyrimidines. . Origin . of atoms in the purine . ring and in the pyrimidine ring.. Components of DNA. Sugar = Deoxyribose. Ribose is missing hydroxyl group (-. OH. ) from 2’C. Phosphate = PO. 4. 3-. Links to the sugar @ either its 3’C or its 5’C. Water (H. OH. ) is lost in the condensation reaction. Dr. Anissa Atif Mirza. Synopsis. Fates of dietary Nucleoproteins/Nucleic Acids.. De novo Biosynthesis of Purines and Pyrimidines.. Salvage of Purines and Pyrimidines. Catabolism of Purines and Pyrimidines. Kumar. Nucleotide Metabolism. PURINE RIBONUCLEOTIDES: formed . de novo. i.e., purines are . not. initially synthesized as free bases. First purine derivative formed is Inosine Mono-phosphate (IMP). Chemistry of purines and pyrimidines. Nucleic Acid. Long chains of repeated nucleotides. A nucleotide consists of:. 1- Nitrogenous base. 2- Pentose sugar. 3- One or more phosphate groups. History. Nucleotide. life . processes. nucleotides . are the . activated precursors . of nucleic . acids. As such, they are necessary for the replication of the genome . an . adenine nucleotide, ATP, is . the universal currency of energy. A guanine . Acid. M.sc.. . Duaa. . falah. pharmacology and toxicology. Uric acid. It is . the final breakdown product of purine metabolism. it circulates in the plasma as sodium urate and is excreted by the kidney. It is derived from nucleic acid that are ingested or come from destruction of tissue cell .. Met.. Purine. Met.. Learning Objectives. 1. How . Are Purines Synthesized? . 2. . How Are Purines Catabolized?. 3. . How Are . Pyrimidines. Synthesized and . . . Catabolized. ?.  . 4. . How Are . OGY Dr. Sinosh Skariyachan, Department of Microbioogy, St. Pius X College Rajapuram, Kasaragod 1 DNA STRUCTURE Introduction - Historical Resume of Nucleic acid discovery  In 1869 Frederick Miesc nucleoside salvage. purine nucleoside ^. ribonucleoside ^. purine ribonucleoside ^. purine ribonucleoside salvage. urate *. purine ribonucleoside *. water-soluble vitamin *. nucleobase-containing small molecule ^. Presented . by. Ms. . P. . . H. . Giri. Department of Microbiology. Deogiri . College, Aurangabad. B.Sc. F. Y.. Semester II. Paper No. V. Basic Biochemistry. Unit 4 Nucleic acids. Ms. . Priyanka. H. .