PPT-Hemophilia Management:

Joint Bleeds and Prophylaxis Factor VIII Measures FVIIIC correlates with bleeding phenotype Interpatient variability Nonlinear relationship with bleed frequency FVIIIC and aPTT assess only plasma matrix. Hemophilia. X-linked . recessive disorder . characterized by the inability . to properly . form blood clots. .. Until recently, hemophilia was untreatable, and only a few hemophiliacs survived to reproductive age because any small cut or internal hemorrhaging after even a minor bruise were fatal.. (. H. aemophilia). By: Morgan Dirienzo. The Royal Disease. Alternate Names and Symptoms. Some alternate names for Hemophilia would be Haemorrhaphilia, or Von Willebrand disease. . The Symptoms for Hemophilia are…. organization that assists and advocates for the bleeding disorders community.. MISSION. [Your Name]. [Date]. First Responders . &. von . Willebrand. Disease. © 2015 Hemophilia Federation of America. All rights reserved.. Recognition and Management of Patients with Hemophilia/von . Willebrand. Disease and Platelet Disorders. Rebecca Schaffer, DDS. Assistant Professor, Special Needs Care Unit. Associate Administrative Director, AEGD. Chemical Basis for Catalytic Activity. Enzymes promote . transition state. (. TS. ).. Transition state favored by tight binding. .. Figure depicts anti-CCR-5 “protease”.. Strategy. : Raise against TS analogs.. Introduction/Overview. Introduction/Overview (cont). Importance of Prophylaxis, and Limitations on Its Application, in Hemophilia B. Key Unmet Need in Hemophilia B:. Reducing Patient Burden of Disease. By: Nam-Y7. Hemophilia was first recognized by the Jews, but not officially named even in the ancient times. . In the 2. nd. century AD, the Talmud, a Jewish collection of Rabbinical writings said that the boys did not have to be circumcised if two brothers died of the disease. In 1800s, it became known as the Royal Disease because many people of royal families died or got the disease. Queen Victoria got Hemophilia but she survived. Alexei, the heir apparent to the Russian royal family, suffered from Hemophilia. In 1950s, the first treatment to hemophilia appeared. It was in a type called “fresh frozen plasma”. Nowadays, we are marching towards a cure but there are two treatments. One is called “gene therapy” and the other is called “Recombinant therapy”. A treatment for hemophilia is replacing old blood clots with new ones.. June. , . 2013. Roger L. Lundblad, Ph.D.. Consultant in Biotechnology. Chapel Hill, North Carolina. http://www.lundbladbiotech.com. And Adjunct Professor, Department of Pathology,. University of North Carolina, Chapel Hill, North Carolina. . Peterson, Owen Comer, Quaevon Anderson, and Grace Hodges. Basic Information . Grace. . Hemophilia A. Classic hemophilia. Factor VIII deficiency. Hemophilia B. Christmas disease. Factor IX deficiency. A new ambition of the World Federation of Hemophilia. WFH Guidelines for the Management of Hemophilia. All recommendations are consensus based.. Srivastava A et al. Haemophilia. 2020;26(Suppl 6):1–158. . Andrew J. . Costandi. , MD, MMM . Children’s Hospital Los Angeles. USC Keck School of Medicine. Faculty Disclosures. None. Learning Objectives. Upon completion of this activity, participants will be able to:. Mehran Karimi MD. Tehran, September 14, 2017. Agenda. Background. Causes of bleeding and Clinical manifestations. Classification of coagulation disorders in neonates. Primary investigation and diagnostic evaluation. Veena Choubey, Rena Malik, and Luis Carlos Zapata Genetics Hemophilia is an X-linked recessive disorder that exists in two forms, hemophilia A and hemophilia B. Hemophilia A is characterized specif . Chelsea Marion, MD. 1,4. , Oluwaseun Odewole, MD, MPH. 2,4. , Sheila Goel, MD. 3,4. . 1. Dept. of Pediatrics, Morehouse School of Medicine, Atlanta, GA. . 2. Dept. of Family Medicine, Morehouse School of Medicine, Atlanta, GA. .