PPT-Impact of Imatinib interruption & duration of prior Hyd

Raafat R Abdel Malek MD FRCR Ass Prof Clinical Oncology Cairo University Egypt Introduction CML is a myeloproliferative neoplasm characterized by presence of BCRABL fusion gene resulting in uncontrolled proliferation of mature and maturing granulocytes. Handle Interruption if necessarySeek interruption if appropriateLeverage Interruption if possible Diverse strategies Diverse strategies Handle Interruption if necessarySeek interruption if appropriate Resistance. Geoffrey L. Uy, M.D.. Associate Professor . of Medicine. Division of Oncology. Natural History of CML. Chronic Phase. Accelerated Phase. Blast Phase. Duration. 3-5 . yrs. , untreated. Varies. By Tara Geraghty. “Interruptions are generally considered to be violations of the rules of conversation”. -Peter . Kunsmann. . Types of interruption (. Orestrom. , 1983). Often disagreement . According to Beattie (1983:124), a study of Ferguson (1977) shows that overlaps are. stromal. tumors. Introduction. Tim Butler. March 8. th. , 2012. Topics for Today. GI . Stromal. Tumors (GIST). KIT Signaling. KIT targeted . therapy. ETV1. Interstitial Cells of . Cajal. Discovered by Ramon .  . A PROBLEM? ………….  .  . 1.Know . the Policyholder’s . Business. 2. .Know the Policyholder’s . Business. 3. Know . the Policyholder’s . Business. What does the Policyholder do?.  . It receives energy from prime mover ( electric motor or engine) and imparts it to fluid.. 2. CLASSIFCATION. Based on principle of operation:. . 1.hydrostatic pump (positive . displacement type). Means to Monitor Service Reliability:. Monthly Interruption Data. Electric Service Standards. Reliability Performance Mechanism (RPM). Basic Measures:. Frequency (SAIFI). Duration (CAIDI). Major Storms as defined in Part 97. Associate Professor . of Medicine. Division of Oncology. Natural History of CML. Chronic Phase. Accelerated Phase. Blast Phase. Duration. 3-5 . yrs. , untreated. Varies. Median. of months. Prognosis. Lateral Protection . Strategies. X.CHEN, C.J.COOK, P.J.FAHEY. S&C Electric Company. CIGRE . – 2015 Grid . of the Future . Symposium. Chicago IL. October 12, 2015. 1. Outline. 2. Quick overview of lateral . . garu. di, O . Dduw. , . . dy. . garu. di,. yw. '. ngweddi. . tra. . bwyf. . byw. , . . dy. . garu. di;. daearol. . yw. . fy. . mryd. : . O . dyro. . nerth. o . hyd. ,. a . mwy. o . I. ntroduction. CML is a clonal myeloproliferative neoplasm. Dysregulated production and uncontrolled proliferation of mature and maturing granulocyte with fairly normal differentiation. Fusion of 2 genes: BCR (or chromosome 22) and ABL1 (on chromosome 9), resulting in BCR-ABL1 fusion gene. Raafat. R. Abdel-. Malek. , MD, FRCR. Ass. Prof Clinical Oncology. Cairo University, Egypt. Introduction. CML is a . myeloproliferative. neoplasm characterized by presence of BCR-ABL fusion gene resulting in uncontrolled proliferation of mature and maturing granulocytes.. A FIP risk criteria 3 ears of imatinib (n= 31) 5 Y ears of imatinib (n= 20) p - value 2 0 1 (5.0 ) 0. 7 3a ) 3 (15 ) 3b 9 (29 ) ) 5 0 1 (5.0 ) 6a 11 (35 ) 6 (30 ) 6b 6 (19 ) 5 (25 ) Vpresented as nu COVID - Employment Law Considerations March 25, 2020 MARSH COVID - 19: Business Interruption and Employment Law Considerations Situation Update 2 Source: World Health Organization, US Centers for Dis