PPT-Molecular Mechanism of Metabolic disorders

Shinichi Oka PhD Department of Cell Biology and Molecular Medicine Rutgers New Jersey Medical School MSBI543 okashnjmsrutgersedu Objectives Leptin Resistance Obese Insulin Resistance. Also its possible for otherwise healthy people to develop severe illness so any one concerned about their illness should consult their doctor There are emergency warning signs that should signal anyone to seek medical care urgently Emergency Warning . Syndrome. in Non-. Diabetics. Vilanova Fillat, M.B.. Falguera Vilamajó, M.. Garriga Badia, A.. Miró Vallvé, N.. Cebrian Aiguadé, C.. Escardó Font, C. Bacompte Jorba, C. Vivas Solé, S.. Solé Llop, G.. Chhavi Agarwal, MD, FAAP, MRCP (UK). Assistant Professor. Division of Pediatric Endocrinology. Objectives. Metabolic Syndrome. Etiology. Relationship of various components . Primary care setting- Screening for the risk factors . Reviewed by . Fei. Chen. Background. Autonomous oscillations in gene expression are found in metabolic, cardiac, and neuronal systems.. Such oscillators have important biological roles, as well as very interesting dynamics.. Prof. Tahir . Shafi. Why should we know about acid base disorders. What are acid base disorders. How to interpret acid base disorder. How to establish the cause. Why to worry about acid base disorders. (a). Revise your knowledge on the properties of enzymes. State what is meant by metabolism and metabolic pathway. State what is meant by an anabolic pathway (and make reference to energy). State what is meant by a biosynthetic reaction. (e). Describe the action of competitive inhibitors. Describe the action of non-competitive inhibitors. Describe the action of feedback inhibition. Describe and identify the impact of each of the above on the rate of reaction and through a graph of results. Combined EM/IM Residency Program. Virginia Commonwealth University Health System. Overview. Physiologic Effects of Acid-Base Disturbances. Traditional (Schwartz-Bartter) Approach. Stewart Method. Fluid Resuscitation. Alok Agrawal, MD, FASN, FNKF. Clinical Associate Professor. WSU, Dayton, Ohio. Arterial Blood Gas. ABG’s - necessary to correctly diagnose AB disorders. Interpret ABG s in conjunction with history, PE and labs. The global molecular diagnostics market was worth USD 15.29 billion in 2020 and is further projected to reach USD 31.98 billion by 2027, at a CAGR of 11.1% during the forecast period (2021-2027). Amino Acid Metabolism DisordersPhenylketonuria PKUHyperphenylalanemia is an amino acid disorder caused by decreased activity impaired synthesis or recycling of phenylalanine hydroxylase or its cofacto Bayu. Lestari. What will be Impaired in This Patient?. Obese. Insulin Resistance?. Dyslipidemia? (High TG, High LDL, Low LDL). T2DM?. Metabolic Syndrome. High prevalence of metabolic . s. yndrome: relation between glucose and lipid metabolism. Family Fact Sheet Positive Result: Blood Spot Screen Result Notication What was found on the newborn screen? The newborn screen that was collected at birth found that your baby has low levels 1 A Disorder s (ICIMD) Carlos R. Ferreira 1 *, Shamima Rahman 2 ,3 , Johannes Zschocke 4 *, ICIMD advisory group 1 National Human Genome Research Institute, National Institutes of Health, Bethesda,