PPT-Estimating “Heritability” using Genetic Data

David Evans University of Queensland The Majority of Heritability for Most Complex Traits and Diseases is Yet to Be Explained Maher 2009 Nature Places the Missing Heritability Could be Hiding In the form of common variants of small effect scattered across the genome. A) is the proportion of genetic variation that is due to phenotypic variation. B) is a property of an individual, not a population. C) means that the trait is genetically based. D) can be measured from the resemblance among relatives. 1. ) A bit of basics. 2) Heritability (Ch 10). 3) Assortative mating (Ch 10). 4) Homework. 5) Questions, thoughts?. A bit of basics. Mean:. μ. x. = . Σ. x. i. / N. = (1+2+2+3+3+4) / 6 = 15/6 = 2.5. Is it all in the GENES?. Discussion – Pair and Share. What is a personality characteristic, talent, or skill that runs in your family?. Who in your family has it?. Make a little family tree chart depicting it. Lipika. Ray. 4th . June 2010. Heritability:. Phenotype (P) = genotype (G) + environmental factors (E). (observed) (unobserved) (unobserved). Variances:. Heritability is defined as ratio of variances, by expressing the proportion of the phenotypic variance that can be attributed to variance of genotypic values:. RACE, IQ AND HERITABILITY 583 son jumped the gun, and that a closer look at the texts resolves the problem in a way that does not necessitate a speculation about Jensen's political motives. More gener An International Twin Study. Amy E. . Steffes. University . of Wisconsin – Eau . Claire . Faculty . Mentor: April . Bleske-Rechek. Background. Emerging adulthood is a time of religious change for many people.. Improvement. Genetic Model. Predicting . Genetic . Levels . Increase . Commercial Profitability . Lauren Hyde. Jackie Atkins. Wade Shafer. Fall Focus, Gettysburg, PA . Sept. 14. th. , 2015. Punnett. Square. New Statistical Approaches. Or . Zuk. . Broad Institute of MIT and Harvard. orzuk@broadinsitute.org. www.broadinstitute.org/~orzuk. Genome . Wide Association Studies (GWAS). 2. l. ength: ~3x10. 9. ACCGAGAGGGTT. common . disease. AKA . –. everything is much harder in a binary trait. Naomi Wray. 1. Missing heritability . psychiatric disorders. N cases. N loci. h. 2. SNP-h. 2. Schizophrenia. 67K. 245. 80. 26. Genes and Inheritance. 2017. ggibson.gt@gmail.com. http://www.cig.gatech.edu. Course Outline. 1. Genes and Inheritance (GG). 2. Molecular Biology of the Genome (JL). 3. . Population and Evolutionary Genetics (JL). Naomi Wray. 2016 Module 18: . Statistical & Quantitative Genetics of Disease. 1. Aims of Lecture 1. If a disease affects 1% of the population and has heritability 80%. We will show why . these statements are . Naomi Wray. 2016 Module 18: . Statistical & Quantitative Genetics of Disease. 1. Misunderstandings in MZ twins. “Estimates of heritability of liability to a number of diseases turned out to be quite high. This was a surprise to those not versed in quantitative genetics who tended to think that low concordances rates in MZ twins implied low heritability.” Fraser (1976) . Associate Professor. Dept. of Genetics and Animal Breeding. PSTU, Barishal Campus. Repeatability. . Important repeated traits are. :. Milk production, egg production, number of offspring of goat in different litters.. Genetics & Genomics Winter School. Group Leader – Statistical Genomics Group. Institute for Molecular Bioscience. The University of Queensland. Aim of this lecture. In this lecture, we will show why these statements are consistent :.