PPT-Mass Spectrometry-Based

Adrenal and Peripheral Venous Steroid Profiling for Subtyping Primary Aldosteronism G Eisenhofer T Dekkers M Peitzsch AS Dietz M Bidlingmaier M Treitl TA Williams . Jeff Johnson. Feb 19, 2014. MS Proteomics in a Nutshell. Ionization. Delivering macromolecules to the MS. Ion Manipulation. Trapping and ejecting . analytes. of interest. Fragmentation. Breaking apart for more information. Keywords. :. Molecular . ion (M. +). Fragmentation. Starter:. Use mini wipe boards to brainstorm what you know about mass spectrometry. A: . Use . the molecular ion peak in an organic . molecule’s .  . Brent Fultz. , California Institute of . Technology. Department of Applied Physics and Materials Science . <. AP. . |. . h. . |. . MS. >. History. Recoil-Free Fraction. Technique, Samples. Tommi Eronen. Max-Planck-Institut für Kernphysik. Heidelberg, Germany. Outline. Penning trap mass spectrometry. Q. = . m. parent. – . m. daughter. . Masses for CKM unitarity tests.... Superallowed beta decay. Andrew Rouff and Ben Berger. A Brief History. 1897- JJ Thomson recorded first mass-to-charge ratio of electrons. 1951- W. Pauli and H. Steinwedel developed first quadrupole mass spectrometer. 1959- K. Biemann applies electron ionisation mass spectrometry. Know what information they can provide. Interpret simple mass spectra graphs. Know some uses of mass spectrometry. A mass spectrometer….. Draw the mass spectrometer. Describe the 5 step process. AS A CARTOON STORY BOARD!. Jonathan A. Karty, Ph.D.. jkarty@indiana.edu. http://msf.chem.indiana.edu . Why Mass Spectrometry. Information is composition-specific. Very selective analytical technique. Most other . spectroscopies. David Horn. Thermo Fisher Scientific . San Jose, CA. Outline. Challenges in the characterization of biopharmaceuticals. Introduction to the new generation of . Orbitrap. TM. . mass spectrometers. Confident intact antibody analysis using the Q . April 15. Bafna. Peptide MS. Instrument software usually detects peaks, and computes features (peak, area, m/z…). April 15. Bafna. m/z. Nobel Citation 2002. April 15. Bafna. Nobel Citation, 2002. April 15. &. Secondary. . ion. . mass. . spectrometry. (SIMS). L. Seda Mut 20970802 . Neslihan . Ötük. 20622809. Beytepe. Ankara. 12.04.2012. Outline. Historical Background of MS. . and. SIMS. What is M. and Andrew Gioe. Computation of Molecular Mass. Mass Spectrum is a plot of intensity as a function of mass-charge ratio, m/z. . Mass-charge ratio can be determined through accelerating an ion.. Conti. Guoan Zhang. Director . Proteomics and Metabolomics Core . Facility. Proteomics & Metabolomics . Core Facility . @. . WCM. Proteomics . & Metabolomics Core Facility . @Weill . Cornell . MS. - based protein/metabolite . Mass Spectrometry deals with the examination of characteristics fragments and arising from the breakdown of organic molecules. The mass spectrum is the plot of relative intensity of the ions agains SOP template 1 Revised: 06 /2019 MTD Standard Operating Procedure (SOP) This Standard Operating Procedure (SOP) describes basic chemical safety information for Mass Spectrometry (MS) . Prior to con