19.2 Amino Acids as Acids and Bases PowerPoint Presentation, PPT - DocSlides

19.2  Amino Acids as Acids and Bases PowerPoint Presentation, PPT - DocSlides

2017-10-17 72K 72 0 0

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When an amino acid with positive and negative charges is overall neutral in charge, it is said to be at its . isoelectric point (. pI. ). .. . Ball-and-stick model of glycine at its . pI. of 6.0.. ID: 596784

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Presentations text content in 19.2 Amino Acids as Acids and Bases

Slide1

19.2 Amino Acids as Acids and Bases

When an amino acid with positive and negative charges is overall neutral in charge, it is said to be at its isoelectric point (pI). Ball-and-stick model of glycine at its pI of 6.0.

Learning Goal Using the zwitterion for an amino acid at its isoelectric point, draw its ionized structures at pH values above or below its isoelectric point.

Slide2

Isoelectric Point

The isoelectric point of an amino acid is the pH at which the charged groups on an amino acid are balanced.the amino acid is neutral.An amino acid can exist asa positive ion if a solution is more acidic (lower pH) than its pI.a negative ion if a solution is more basic (higher pH) than its pI.

Slide3

Ionized Forms of Amino Acids

The pI values for nonpolar and and polar neutral amino acids are from pH 5.1 to 6.3.Alanine has a zero overall charge at its pI of 6.0 with a carboxylate anion (— COO−) and an ammonium cation(—NH3+).

Slide4

Ionized Forms of Amino Acids

Alanine adds an H+ to the carboxyl group (— COO−) when the solution is more acidic than its pI (pH < 6).

Slide5

Ionized Forms of Amino Acids

At a pH higher than 6.0, the — NH3+ group loses H+ and forms an amino group — NH2 that has no charge.Because the — COO− group has a charge of 1−, alanine has an overall negative charge (1−) at a pH higher than 6.0.

Slide6

Ionized Forms of Amino Acids

Slide7

Ionized Forms of Polar Acidic and Polar Basic Amino Acids

Slide8

Study Check

CH

3

CH

3

+

|

|

H

3

N

CH

COOH

H

2

N

CH

COO

(

1)

(

2)

Which structure represents

A. alanine at a pH above its

pI

?

B. alanine at a pH below its

pI

?

Slide9

Solution

CH

3

CH

3

+

|

|

H

3

N

CH

COOH

H

2

N

CH

COO

(

1)

(

2)

Which structure represents

A. alanine at a pH above its

pI

?

(2)

B. alanine at a pH below its

pI

?

(1)

Slide10

Study Check

Consider the amino acid leucine with a pI of 6.0. A. At a pH of 3.0, how does leucine change?B. At a pH of 9.0, how does leucine change?

Slide11

Solution

Consider the amino acid leucine with a pI of 6.0.A. At a pH of 3.0, how does leucine change? Because the pH of 3.0 is more acidic than the pI at 6.0, the —COO− group gains an H+ to give — COOH. The remaining — NH3+ gives leucine an overall positive charge (1+). B. At a pH of 9.0, how does leucine change? Because a pH of 9.0 is more basic and above the pI of leucine, the — NH3+ loses H+ to give — NH2. The remaining COO− gives leucine an overall negative charge (1−).


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