PPT-Effect of cmvIL-10 on Ubiquitin mediated C-X-C receptor 4 signaling.

Kiran Hina Tajuddin Juliet Spencer Abstract Methods Results Conclusions Human cytomegalovirus HCMV manipulates the immune system of its host by encoding viral proteins that imitate host cytokine and chemokine pathways The HCMV gene UL111A encodes a homolog of human interleukin10 hIL10 known as cmvIL10 cmvIL10 has many functions including upregulating signaling from human CXC chemokine receptor4 CXCR4 signaling in response to its known ligand CXCL12 cmvIL10 promotes increased intracellular calcium flux and cell migration in response to CXCL12CXCR4 that could assist in viral dissemination Recent studies have shown that extracellular ubiquitin UB is also a natural ligand for CXCR4 This study will focus on whether cmvIL10 also impacts UB mediated CXCR4 signaling and will examine the effects of cmvIl10 on UB induced cell proliferation migration and cell signaling pathways This research will lead to identify the possible role of cmvIL10 in manipulating host cell signaling pathways during virus infection. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Dr. SA . Ziai. Pharmacology. Pharmacology . can be defined as the study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting normal body processes. . Pharmacodynamics. Seyed. Ali . Ziai. Receptor. Pharmacologic antagonists. Macromolecular Nature of Drug Receptors. Regulatory proteins. Enzymes. Transport proteins . Structural proteins. . Receptor- Effector Coupling. Control of the Cell Cycle. Intracellular signaling. Pathways initiated by ligand binding to receptors, usually plasma membrane proteins. Modulate cell growth, metabolism, death, differentiation, movement, and invasion. Cell-to-cell . signaling. : . Important . to both multicellular . & unicellular . organisms. . H. elps coordinate activities & . events necessary for . multicellular . organism to develop from . Kuby Immunology. , . 7e: Chapter 3. Essential Concepts – 1. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals are usually generated by the binding of a ligand to a complementary cell-bound receptor. Skochko. Chris Gilbertson. Reveals Important Features of one’s surroundings. Is it poisonous here? . Have things died here?. Is this food?. The absence of the sense of smell is called “Anosmia.”. Y. He. , S. B. Wiseman, X. Zhang, M. . Hecker. , P. D. Jones, M. G. El-Din, J. W. Martin, J. P. . Giesy. .. Oil Sand Process Water (OSPW). The extraction process results in the production of large volumes of wastewater, commonly referred to . NEIL MEHTA. BIOL 445.001. http://www.bcm.edu/pediatrics/cardiology/TGFBR2. http://en.wikipedia.org/wiki/TGF_beta_receptor_1. CELL SIGNALING PATHWAYS. HETERO-TETRAMERIC RECEPTOR COMPLEX FORMS UPON BINDING TO LIGAND (TGF. JOEBXJ7PMVNFrSUJDMFrQBHFT14t1524272415252414t1524274t22862747155147b1514317415632154247515214t43151424747154715224515311t15113424t22862117b524715n416N423281415145b27f214b4b4322811r1n4281n151565DD611rt Signal Receptors. . BIOL 5190/6190 Cellular & Molecular . Singal. Transduction. Prepared by Bob Locy. Last modified -13F. Intracellular Signal Receptors. Steroid hormone receptors. . Other . Lipophillic. AND . MOTILITY (BIOL 3373) . WHAT IS The CELL SIGNALING?. 2. How cells receive and respond to signals from their surroundings. On one hand, cell signaling regulates gene expression and controls the cell fate (proliferation, motility, differentiation and programmed cell death, or apoptosis).. Introduction. Cell signaling: . a biological mechanism that occurs in cells which gives cells an ability to receive or generate the signals in response to their surrounding environment.. Cell to cell communication . F. 2. m/m. mutant. Phenotype. A maternal effect is the phenomenon where the . genotype. of a mother is expressed in the . phenotype. of its offspring, unaltered by paternal genetic influence. m/+ x m/+ .