PPT-Challenges in Computational & Functional Genomics

Igor Ulitsky the branch of genetics that studies organisms in terms of their genomes their full DNA sequences Computational genomics in TAU Ron Shamirs lab focus on gene expression and regulatory networks. The network concept Various types of networks (represented by weighted, directed, coloured graphs) became widely applied to describe complex systems in the last decade. Modelling a complex system as a NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). NHGRI strategic plan. What does the NIH think genomics should be for the next 10 years?. [Nature, Feb. 2011]. The Essence of Genomics. (according to NHGRI). Comprehensiveness. . Genomics . aims to generate complete data sets. Although relatively easy to define and measure for a genome sequence, attaining comprehensiveness can be more challenging for other targets (for example, functional genomic elements or the ‘proteome’). Chi-Han Peng, Yong-Liang Yang, Fan . Bao. , Daniel Fink, . Dong-Ming Yan, Peter Wonka, . Niloy J. . Mitra. Functions. of street networks. London. Phoenix. Traffic demand, land use, topology constraints, etc.. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Recombination breakpoints. Family Inheritance. Prof. William Stafford Noble. Stuff folks liked. Good pace. x3. Powerpoint. was easy to follow. x2. Really appreciate reading the program step by step. x2. Helpful to go over the sample problems at the beginning of class.. selection, . regulation, epigenomics, . disease. Manolis Kellis. MIT Computer Science & Artificial Intelligence Laboratory. Broad Institute of MIT and Harvard. Goal: A systems-level understanding of genomes and gene regulation:. Smoking Research . and Application. Elizabeth Prom-Wormley, MPH, PhD. Division of Epidemiology, Department of Family Medicine and Population Health. Virginia Institute for Psychiatric and Behavioral Genetics. Outline : Functional genomicsIntroductionRelation between genotype and phenotypeEight model organismsE. coli; yeast; ArabidopsisC. elegansDrosophilazebrafish; mouse; humanFunctional genomics using re from NHGRI’s . Planning . Workshop on the Future Opportunities . for . Genome Sequencing . & Beyond. Mark Gerstein & Rick Myers. Recommendations related to genome function. . Part 1: Workshop summary (Mark). Bionano Genomics, San Diego, California, United States of America. Abstract. Pat Lynch, PhD. Background. Generating high-quality finished genomes replete with accurate identification of structural variation and high completion (minimal gaps) remains challenging using short read sequencing technologies alone. The . What . is . Functional. . Genomics?. RNA . Transcription/Gene. . Expression. Measuring Gene. . Expression. Microarrays. High-throughput. . Sequencing. Transcriptional. . Regulation. Transcription. Ian Green. Clinical Engagement and Education Business Manager. Strategy. Work undertaken by Genome One (part of the . Garvan. Institute). Work underway. Completion date . –. 17. th. , March 2017. Ravi Madduri. madduri@anl.gov. Joint work with Paul . Davé. , Lukasz . Lacinski. , Alex Rodriguez, . Dinanath. . Sulakhe. , Ryan Chard and Ian Foster. Globus Genomics is developed, operated, and supported by researchers, developers, and .