PPT-Epigenetics Originally defined as “ the branch of biology which studies the causal interactions

Waddington 1942 The study of any potentially stable and ideally heritable change in gene expression or cellular phenotype that occurs without changes in WatsonCrick basepairing of DNA . Interface between Physics and Biology. . Shekhar. C. . Mande. Centre for DNA Fingerprinting and Diagnostics. Hyderabad. Emerging Paradigm of Modern Practice of Science. Integration of all branches of sciences (learning)…….. between . normative (philosophical/ computational) . theories of causation and empirical research on causal . cognition. . Jim Woodward. HPS, Pittsburgh. Causality: Perspectives from Different Disciplines. Kevin Ferriter. Mariah Minder. From Yesterday…. Do you think your brain cell and your blood cell have the same DNA sequence?. Genetics. Every cell contains all of your DNA. Not every cell expresses all of your DNA. Small. . by the. Big. Phyllis McKay . Illari. University of Kent. 1 The usual problem. Explanatory Regress. Gap-o-phobia. Gap-o-phobia. Gap-o-phobia. Gap-o-phobia. ?. Gap-o-phobia. ?. HELP! . I fell out of the bottom of the world!. Children’s outcomes and family background. Claire Crawford. Introduction. UK has relatively low intergenerational mobility. Correlation between parents and children’s income is relatively high. Intergenerational elasticity of 0.29 for those born in Britain in 1970 (. Assoc. . Prof. Dr. Şehnaz . Şahinkarakaş. Introduction to Causal-Comparative Research. A . causal-comparative. . study. is. a . study in which the researcher attempts to determine the cause, or reason, for pre-existing differences in groups of . Waddington, 1942. “The study of any potentially stable, and ideally, heritable change in gene expression or cellular phenotype that occurs without changes in Watson-Crick base-pairing of . DNA” . : A Mechanist Perspective. Stuart Glennan. Butler . University. The singularist and generalist view of causation. The. generalist view: Particular events are causally related because they fall under general laws. : A Mechanist Perspective. Stuart Glennan. Butler . University. The singularist and generalist view of causation. The. generalist view: Particular events are causally related because they fall under general laws. Epigenetics comprises (hereditary) changes in gene expression without altering the DNA sequence . Epigenetics is a biological subdiscipline that deals with questions of development, heredity, gene regulation and evolution . JABLONKA & LAMB: CHANGING CONCEPT OF EPIGENETICSment. We will then consider the practical importance of epigenetics in med-icine, agriculture, and ecology and, finally, look at the implications thatre Gene-Environment Interactions. Complex diseases result from an interplay of genetic and environmental factors. Why study Gene-environment Interactions (. GxE. )?. Studies of . GxE. may help identify and characterize genetic and environmental effects.. ‘Epi’: On top of. . Definition:. The . study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.. DNA. How many cell types are in the human body?. modified. human proteome . Human proteins exhibit highly complex patterns of posttranslational modifications (PTMs) that govern their structure and function. These modifications are omnipresent in human health and disease. However, technical barriers have limited the study of PTMs which keeps the knowledge of our proteome in a persistent state of “physiological dark matter”. .