PPT-Cholesterol and Cholesteryl

Esters Cellular cholesterol metabolism is tightly regulated to synthesis of normal cell membrane without significant intracellular accumulation phagocytic cells macrophages may become overloaded with lipid . High blood cholesterol is one of the major risk factors for heart disease A risk factor is a condition that increases your chance of getting a disease In fact the higher your blood cholesterol level the greater your risk for developing heart disease Hypertension. CMT Training. The Center for Life Enrichment. Section 1. High Cholesterol. What is it?. Cholesterol is necessary for proper digestion, hormone balance, and healthy cell membranes. When the blood cholesterol is too high, it forms deposits or plaque inside the walls of arteries. Learning outcome. Most cholesterol is synthesised by the liver from saturated fats in the diet. Cholesterol is a component of cell membranes and a precursor for steroid synthesis. High-density lipoprotein (HDL) transports excess cholesterol from the body cells to the liver for elimination. This prevents accumulation of cholesterol in the blood. Low-density lipoprotein (LDL) transports cholesterol to body cells. Most cells have LDL receptors that take LDL into the cell where it releases cholesterol. Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas. A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis. . BIOSYNTHESIS OF CHOLESTEROL. Cholesterol is doubtless the most publicized lipid, notorious because of the strong correlation between high levels of cholesterol in the blood and the incidence of human cardiovascular diseases.. The Good, the Bad and the Ugly. What is Cholesterol?. Cholesterol is a waxy fat steroid. It is manufactured in the :. Liver. Intestines. Adrenal glands. Sex organs. Cholesterol is only synthesized in animals. Cholesterol. Is the most abundant . steroid. in the body.. Is a . waxy. substance found in all of the body cells. . Has . methyl. CH. 3. - groups, alkyl chain, and -OH attached to the steroid nucleus.. Beth Kalicki. Heli. J. Roy, PhD, RD. Pennington Biomedical Research Center. Cholesterol Trends. Blood cholesterol levels correlate with weight. However, lean individuals can have high cholesterol levels.. What is Cholesterol?. Cholesterol is a waxy fat steroid. It is manufactured in the :. Liver. Intestines. Adrenal glands. Sex organs. Cholesterol is only synthesized in animals. The Good…. Cholesterol is a very important compound!. Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. CVS. 2018/2. ND. SEMESTER. • Four major groups of lipoproteins are recognized: Chylomicrons transport lipids resulting from digestion Lipid Metabolism and . absorption.Derived. from intestinal absorption of TG . . ????????????????? ? Cholesterol is a fatty substance, vital for good health. It helps form cell membranes, various hormones, bile and vitamin D. We get some cholesterol from our diet but most is made Peter Espenshade. Department of Cell Biology . Cellular Control of Metabolism. Jürgen Berger/Max Planck Institute. Cells require tight regulation of metabolism to maintain . homeostasis and viability.. Lipoprotein Metabolism. Dr. . Usman. . Ghani. Objectives. By the end of this lecture, the First Year students will be able to:. Define and list the types, structure and composition of . lipoproteins. Dr. Carolyn K. Suzuki. 1. To compare and contrast the properties of apolipoprotein particles (e.g. chylomicrons, LDL, HDL), with respect to their composition, metabolism and transport. . To distinguish the different biochemical pathways that can be potentially targeted pharmacologically to control plasma apolipoprotein levels and manage cardiovascular disease..