PPT-Endocrine resistance: molecular pathways and rational development of targeted therapies

Grazia Arpino Università di Napoli Federico II Current Endocrine Therapy Tamoxifen aromatase inhibitors Limited by denovo or acquired endocrine resistance. chemotherapy, targeted molecular therapies and other promising modalities, the Proton Therapy Center is leading the next generation of lung cancer care, research, education and prevention. Jame Dr Glen Clack. Senior Medical Director. Oncology Translational Medicine Unit. AstraZeneca . Challenges and Opportunities. 2. Author | 00 Month Year. Set area descriptor | Sub level 1. Barriers Perceived by Pharma. targeted. : . limiti e successi nelle metastasi cerebrali. 55 ° Congresso Nazionale SNO. Como. , 22-24 Aprile , 2015. Riccardo Soffietti. U. O. Neuro-Oncologia. Università e Città della Salute e della Scienza, Torino.. Stuart S. Winter, MD. Pediatric Hematology/Oncology. The T. John Gribble Endowed Chair. Background- Acute Lymphoblastic Leukemia in Children & Young Adults. Risk Classification Strategy. Through improved approaches to risk classification, therapy intensification, and supportive care, children and young adults with acute lymphoblastic leukemia (ALL) have an overall survival rate that currently exceeds 80%. Insight Therapies. Relationship Therapies. Behavior Therapies. Cognitive Therapies. Biological Therapies . Evaluating the Therapies. Culture- and Gender- Sensitive Therapies. Why Seek Therapy?. Approaches to Therapy. David Houghton BPharm MSc GPhC. Oral Complications in Cancer and Palliative Care. Monday . 12 May 2014. Definition:. Stomatitis – general term : includes inflammation and ulceration of mucosal lining from any cause. Nathan Pennell, M.D., Ph.D.. September 6, 2014. Objectives. Discuss the role of chemotherapy in molecularly defined populations. Discuss the addition of chemo and/or bevacizumab (Avastin) to targeted therapy. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.. 13. Objectives:. Describe the vital function of the endocrine system. State the description and primary functions of the organs and structures of the endocrine system. Identify some of the hormones produced. Targeting endocrine-resistance pathways in breast cancer Clara Natoli, Chieti Endocrine responsive breast cancer Luminal A High expression of ER & ER-related genes Lower rs 3 - 1 3. Gonadotropin Releasing Hormone:Gonadotropin:Sex Steroid Signaling Pathway 3.1 Hypothalamus - Pituitary - Gonad (HPG) Axis 3.1.1 Structure 1. In vertebrates, reproduction is primarily cont HOPC. Mrs GV is a 78 year old women who presented to Cabrini ED with acute dyspnoea is the setting of recent malignant pleural effusion in the setting of Metastatic Breast Ca.. Nov 2010: Self Detected left breast lump (AJCC Stage . What is it?. The endocrine system (ES) regulates long term changes in the body such as growth and development. . It also controls many of your body’s daily activities and influences . almost every cell, organ, and function of our . How they work and the future of medicine. Every cell has a set lifespan. After that lifespan has been reached, a cell undergoes apoptosis (programmed cell death). The life(span) of a cell. How does apoptosis work?.