PPT-Genetic disorders of haemoglobin

Normal adult blood contains three types of haemoglobin The major component is haemoglobin A with the molecular structure α 2 β 2 The minor haemoglobins contain ɣ fetal . Haemoglobin has ONE job – to carry oxygen around the body. It is a large protein with a quaternary structure. What are proteins?. Proteins are made up of C, H, O, N and some S and P. Transport proteins such as haemoglobin carry oxygen.. Introduction. There are thousands of . genetic disorders. that affect humans, some of which can have profound effects on a person's quality of life. Genetic disorders are . passed from parents to offspring in the genetic . Warm Up: 2/1/2017. Instructions: Turn in your Cornel notes on Mutation Types and Causes to the turn it in box on my desk & start working on answering the . questions below:. What is a mutation? . MAY9,L9o8.1]THETRAININGOFMENTALDEFECTIVES.[1J097possiblybeduetotheviscosityoftheblood.-ParkesWebershowedthistobemuchabovethenaturalinhiscases,andtheobsetvationhasbeenconfirmed.Butthiscouldonlyactbydel Polydactyly. Down Syndrome. Hemophelia. Progeria. Hypertrichosis. Sickle Cell Anaemia. INTRODUCTION. What is genetic diseases/disorders?. The human body is composed up of cells , each one specializing a particular function like sensing light, smelling . Abeer. . Anwer. Ahmed. Sickle cell disease is a group of . haemoglobin. disorders . resulting from . the inheritance of the sickle β‐. globin. gene. . Sickle cell disease (SCD) is . an. . autosomal. مؤيد . علو. ش. Lec. . 2. Thalassaemias. Objectives:. 1-Define thalassemia and its main types(. β. and . α. ). 2- Know the . genetic . lesions of each of . β . and . α. thalassemia. 3-Know the difference between thalassemia minor and major.. MB;BS(Ilorin), FWACP(. Paed. ). Outline. Intro /def. Normal haemoglobin structure / function. Classification of haemoglobinopathies . Structural Hb Variants. Thalassaemias. Epidemiology. Clinical features. Key wordsAnaemia, hypochromic microcytic; Erythrocyte indices; Haemoglobin H disease; Mean corpuscularvolume; Thalassaemia, beta Children's Haematology and Cancer Centre, Mount ElizabethHospital, L Page 1 of 28 UnitedHealthcare Commercial Medical Policy Effecti ve 10/01/2021 Proprietary Information of UnitedHealthcare. Copyright 202 1 United HealthCare Services, Inc. UnitedHealthcareCommercia anaemia. Assist.Prof. . :. Dr.Maysem. M. . Alwash. . Erythropoiesis. is the generation of red blood cells . .. .. -. All the circulating blood cells derive from . pluripotential. stem . cells in the marrow. Oxygen dissociation curves show partial pressure of oxygen, plotted against what?. If a species’ haemoglobin has a high affinity for oxygen, what does this mean?. Why does CO. 2. concentration alter Haemoglobin’s affinity for oxygen?. . Assist. Prof. . Dr.Maysem. . Mouayad. . Alwash. . Note:. The . thalassaemias. are classified into . α. -, . β. -, . δβ. -, . γδβ. -, . δ. -, . γ. - and . εγδβ. -thalassaemias, according to the type of globin chain(s). Dr.Maysem. M. . Alwash. Sickle cell . disaese. Sickle cell disease (SCD) is an inherited chronic . haemolytic. . anaemia. . whose clinical manifestations arise from the tendency. of the . haemoglobin.