PPT-Cholinergic drugs & NMJ blockers

By Qingwei Zhang Olivia STRUCTURE ANS RECAP CHOLINOMIMETICS CHOLINOCEPTOR AGONISYS CHOLINOCEPTOR ANTAGONISTS NEUROMUSCULAR JUNCTION BLOCKING DRUGS ANS Recap SALIVARY GLANDS Thick viscious secretion. Define cholinergic Drugs ?. Cholinergic Drug are agent which produce the action similar to those seen by the stimulation of parasympathetic nervous system.. 2) Write the enzyme responsible for metabolism of acetylcholine . Define cholinergic Drugs ?. Cholinergic Drug are agent which produce the action similar to those seen by the stimulation of parasympathetic nervous system.. 2) Write the enzyme responsible for metabolism of acetylcholine . Introduction. Autonomic . nervous system (. ANS). A. utomatic. , self-governing, or . involuntary. No . conscious . control. Divided . into . sympathetic (alert system) and . parasympathetic nervous . Neuromuscular Blockers. Prevent acetylcholine from activating nicotinic. M. Cause muscle relaxation (paralysis). No oral forms. Cannot cross . Blood-brain barrier . No impact on CNS (paralysis, not sedation). Chapter 14 Drugs Affecting The Nervous System The nervous system controls, directs and coordinates bodily functions 2 main divisions of the nervous system: Central Nervous System (CNS) - brain and spinal cord Week 1. By Renee . McCroskey. BSN, RN. Pharmacology Fundamentals. Chapters 1-4. Things to think about…. What . drug is ordered. Name (generic and trade) and drug classification. Mechanism of action. 11/10/17 . Case 1: . 18 month old girl brought the ER by ambulance after grandmother was unable to wake her up from a long nap. . No concurrent illness. On exam: Shallow breathing, moans and withdraws in response to pain, does not open her eyes. Rest of physical exam is normal. . ACH is synthesized in the cholinergic neurons from choline and acetyl CoA then stored in synaptic vesicles then it will be release into synaptic gap to bind post synaptic receptors and lead to biological response.. Cholinergic antagonist is a general term for agents that bind . to . cholinoceptors. (muscarinic . or nicotinic) and prevent the . effects . Sympatholytics. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. These . that bind . to . cholinoceptors. (. muscarinic. . or nicotinic) . and prevent . the effects of . acetylcholine (. ACh. ) and . other . cholinergic agonists. The most clinically. useful of these agents are selective . www.sdh.sk.ca/RxFiles Hypoglycemic Drug Interactions 1. What drugs should not be used in combination with oral hypoglycemics?Despite numerous interactions affecting hypoglycemics, few are of major sig Diuretics. Sympathoplegic agents. Direct vasodilators. Agents that block action of angiotensin. Most anti-HT drugs ↓ BP by ↓ CO &/or ↓ PVR. Mechanisms for Controlling Blood Pressure (BP):. Mild HT can be controlled with a single drug;. muscarinic. antagonist / . muscarinic. blocker.. OBJECTIVES. Classify & describe cholinergic antagonists. Explain actions, therapeutic uses & adverse reactions of cholinergic antagonists. Cholinergic antagonist / Cholinergic blockers.