PPT-Cholinergic drugs & NMJ blockers

By Qingwei Zhang Olivia STRUCTURE ANS RECAP CHOLINOMIMETICS CHOLINOCEPTOR AGONISYS CHOLINOCEPTOR ANTAGONISTS NEUROMUSCULAR JUNCTION BLOCKING DRUGS ANS Recap SALIVARY GLANDS Thick viscious secretion. Define cholinergic Drugs ?. Cholinergic Drug are agent which produce the action similar to those seen by the stimulation of parasympathetic nervous system.. 2) Write the enzyme responsible for metabolism of acetylcholine . Define cholinergic Drugs ?. Cholinergic Drug are agent which produce the action similar to those seen by the stimulation of parasympathetic nervous system.. 2) Write the enzyme responsible for metabolism of acetylcholine . SYSTEM. . . TWO MAJOR DIVISIONS. PARASYMPATHETIC. -ganglia close to organ innervated. -. preganglionic. fibers are . myelinated. and long. -postganglionic fibers short and . unmyelinated. SYMPATHETIC. Neuromuscular Blockers. Prevent acetylcholine from activating nicotinic. M. Cause muscle relaxation (paralysis). No oral forms. Cannot cross . Blood-brain barrier . No impact on CNS (paralysis, not sedation). Cholinergic Agonists Direct-Acting Cholinomimetics Direct-Acting Cholinergic Agonists (N & M) Cholinergic agonists (parasympathomimetics) mimic the effects of ACh on cholinoceptors. These agents broadly classified into Classify adrenergic antagonists . Describe actions, therapeutic uses & adverse effects of adrenergic antagonist.. b. Discuss the role of autonomic drugs in central nervous system disorders. c. Enlist drugs used in glaucoma. ACH is synthesized in the cholinergic neurons from choline and acetyl CoA then stored in synaptic vesicles then it will be release into synaptic gap to bind post synaptic receptors and lead to biological response.. Sympatholytics. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. These . Abd. Al- Kader. PhD Pharmacology. THE CHOLINERGIC . NEURON. 1. The . preganglionic. fibers terminating in the . adrenal medulla. 2. The autonomic ganglia . (both parasympathetic and sympathetic. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. Cholinergic Transmission. ., . Ph.D.. Department . of. Cell Biology .  . Genetics. Faculty. . of. Science, . Palacky. University Olomouc. Intoxications. : . Symptoms. . & . Therapy. „. The . dose makes the poison" . . Dr.. Rashmi . Rekha. Kumari. Asstt. . Prof, . Deptt. . Of Pharmacology & Toxicology,BVC,Patna-14. Cholinergic transmission. Neurohumoral. transmission . either at synapse or neuroeffector junction in which acetylcholine act as a humoral agent(neurotransmitter) for transmission of action potential across the junction. C. Jenkins aA MD CM FRCPC Peter J. Scoates a sc MD FRCPC CONTENTS Physiology - calcium/calcium channel blockers Uses of calcium channel blockers Traditional Angina pectoris Arrhythmias Hypertension on. . intestine and % of antagonism. .. PHL 313 (Lab. . 2). 2. 3. The . “Muscarinic Actions” . -- Similar to those of. . parasympathetic . stimulation. • . (M1): CNS, PNS, gastric parietal cells .